INT202353

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ccm2) cytoplasm (Ccm2)
Anatomy Link Frequency
8-cell stage 1
Ccm2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 13 21.00 Low Low
cytokine 26 19.56 Low Low
depression 13 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 26 76.44 Quite High
Stress 104 62.36 Quite High
INFLAMMATION 13 20.76 Low Low
Increased Venous Pressure Under Development 52 5.00 Very Low Very Low Very Low
Reprotox - General 3 13 5.00 Very Low Very Low Very Low
Depression 13 5.00 Very Low Very Low Very Low
Shock 13 5.00 Very Low Very Low Very Low
Carcinoma 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both Ccm2 and Map2k6 mRNA levels decreased significantly from 1-cell levels to those observed at the 2-cell, 4-cell, and 8-cell stage (P ?
Transcription (levels) of Ccm2 in 8-cell stage
1) Confidence 0.71 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Effect of 460 mOsm hyperosmotic treatment on Ccm2 transcripts and CCM2 protein
Transcription (transcripts) of Ccm2
2) Confidence 0.71 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Qualitative RT-PCR methods resulted in the detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6 and Map2k4 producing the expected size amplicons of 371 bp, 374 bp, 387 bp, 395 bp and 363 bp respectively throughout mouse preimplantation development in all 3 experimental replicates (Figure 2A).
Transcription (detection) of Ccm2
3) Confidence 0.71 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
No significant differences (P > 0.05) in relative Ccm2 mRNA transcript levels were observed between blastocysts cultured in the KSOMaa + 0.2 M sorbitol and blastocysts cultured in the normal KSOMaa medium control group at any of the investigated time-points (Figure 5A).
Transcription (transcript) of Ccm2
4) Confidence 0.71 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Effect of 460 mOsm hyperosmotic treatment on Ccm2 transcripts and CCM2 protein
Transcription (transcripts) of CCM2 protein
5) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
/Mapk14 (Assay ID: Mm00442497_m1), were used along with the Custom TaqMan® Gene Expression Assays described above for Ccm2 and Luciferase.
Transcription (described) of Ccm2
6) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6, and Map2k4 during mouse preimplantation development
Transcription (Detection) of Ccm2
7) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
No significant differences (P > 0.05) in relative Ccm2 mRNA transcript levels were observed between blastocysts cultured in the KSOMaa + 0.2 M sorbitol and blastocysts cultured in the normal KSOMaa medium control group at any of the investigated time-points (Figure 5A).
Transcription (levels) of Ccm2
8) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Though changes were not detected in localization or steady state mRNA transcript levels of CCM2 following hyperosmotic treatment, our results did reveal a significant increase in CCM2 immunofluorescence in blastocysts treated for 15 minutes in 0.2 M sorbitol (460 mOsm), but not 1.4% glycerol (460 mOsm).
Transcription (levels) of CCM2
9) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.06 Pain Relevance 0
Qualitative RT-PCR methods resulted in the detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6 and Map2k4 producing the expected size amplicons of 371 bp, 374 bp, 387 bp, 395 bp and 363 bp respectively throughout mouse preimplantation development in all 3 experimental replicates (Figure 2A).
Transcription (transcripts) of Ccm2
10) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
Though changes were not detected in localization or steady state mRNA transcript levels of CCM2 following hyperosmotic treatment, our results did reveal a significant increase in CCM2 immunofluorescence in blastocysts treated for 15 minutes in 0.2 M sorbitol (460 mOsm), but not 1.4% glycerol (460 mOsm).
Transcription (transcript) of CCM2
11) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.06 Pain Relevance 0
Detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6, and Map2k4 during mouse preimplantation development
Transcription (transcripts) of Ccm2
12) Confidence 0.53 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
Ccm2 (Figure 2B) and Map2k6 (Figure 2E) mRNA steady state levels were significantly highest at the blastocyst stage (P ?
Transcription (levels) of Ccm2
13) Confidence 0.46 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0

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