INT202728

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
macrophages 1
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 10 96.28 Very High Very High Very High
Acupuncture 42 89.56 High High
Inflammatory mediators 4 68.84 Quite High
cytokine 78 64.00 Quite High
Inflammation 52 41.76 Quite Low
Pain 52 5.00 Very Low Very Low Very Low
long-term potentiation 14 5.00 Very Low Very Low Very Low
Pain threshold 14 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 11 5.00 Very Low Very Low Very Low
transcutaneous nerve stimulation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 212 97.84 Very High Very High Very High
INFLAMMATION 66 95.96 Very High Very High Very High
Cancer 10 50.00 Quite Low
Necrosis 6 50.00 Quite Low
Pain 66 5.00 Very Low Very Low Very Low
Insulin Resistance 20 5.00 Very Low Very Low Very Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B1/p105, triggering its proteolysis and the release and activation of Tpl2.
Localization (release) of Tpl2
1) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.59 Pain Relevance 0.11
Indeed, in nonstimulated macrophages, Tpl2 is stabilized and is inactive due to its binding to NF-?
Localization (stabilized) of Tpl2 in macrophages
2) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.08
Change of EST
Localization (Change) of EST
3) Confidence 0.39 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.04
EST increase was reported by 5 (23%) of the 22 women, unchanged by 11 (50%) and a decreased EST by the remaining 6 (27%) women.
Neg (unchanged) Localization (decreased) of EST
4) Confidence 0.39 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.04
This is an EST and is not found in LocusLink [20].
Neg (not) Localization (found) of EST
5) Confidence 0.04 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1784106 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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