INT20276

Context Info Confidence 0.07 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.04 Pain Relevance 1.98

extracellular region (Abo) transferase activity, transferring glycosyl groups (Abo) Golgi apparatus (Abo) carbohydrate metabolic process (Abo)

Anatomy Link Frequency liver 1 tail 1 Abo (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 21 99.98 agonist 31 93.36 Inflammation 15 87.12 metalloproteinase 5 80.12 Inflammatory response 2 59.60 cva 2 25.00 Bile 9 22.68 COX2 2 5.00 cytokine 2 5.00 cINOD 2 5.00

Disease Link Frequency Relevance Heat Necrosis 3 97.28 Injury 5 94.48 INFLAMMATION 18 87.12 Hepatotoxicity 3 75.00 Pressure And Volume Under Development 1 56.96 Poisoning 1 51.76 Obesity 14 5.00 Disorder Of Lipid Metabolism 14 5.00 Targeted Disruption 10 5.00 Congenital Anomalies 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Eighteen hours after the administration of a hepatotoxic dose of AAP, there is a statistically significant decrease of the activity of aniline hydroxylase, ethylmorphine demethylase, uridine diphosphoglucuronyl transferase, glutathione-S-transferase, NADPH-cytochrome-c-reductase, the P-450 content and a 5-fold increase of TBA-reactive products.

Positive_regulation (increase) of transferase associated with paracetamol

1) Confidence 0.07 Published 1990 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 2130626 Disease Relevance 0.07 Pain Relevance 0.76

APAP increased alanine transferase (ALT) levels (41.1-fold) and resulted in centrilobular hemorrhagic necrosis at 6 h.

Positive_regulation (increased) of alanine transferase associated with necrosis and paracetamol

2) Confidence 0.07 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15456921 Disease Relevance 0.46 Pain Relevance 0.96

While others, such as hypoxanthine-quanidine phosphoribosyl transferase, with a CPE and a short poly A+ tail are polyadenylated during maturation.

Positive_regulation (polyadenylated) of transferase in tail

3) Confidence 0.03 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0 Pain Relevance 0

The observed increase in plasma alanine amino transferase activity in patients treated with fibrates may thus be related to direct regulation of Gpt transcription, rather than drug-induced liver injury. 10.

Positive_regulation (increase) of plasma alanine amino transferase in liver associated with injury

4) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.50 Pain Relevance 0.26

General Comments

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