INT202983

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 11.98
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (STC2) cell-cell signaling (STC2)
Anatomy Link Frequency
brain 3
lobe 1
STC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1496 99.70 Very High Very High Very High
anesthesia 11 80.64 Quite High
epidural 22 79.44 Quite High
ischemia 11 70.88 Quite High
cerebral cortex 44 64.80 Quite High
agonist 22 50.36 Quite High
Dopamine 11 34.72 Quite Low
Deep tissue 11 20.04 Low Low
Disease Link Frequency Relevance Heat
Contusions 11 99.90 Very High Very High Very High
Injury 132 99.84 Very High Very High Very High
Cv General 3 Under Development 1463 99.70 Very High Very High Very High
Brain Injury 286 99.56 Very High Very High Very High
Brain Disease 11 99.50 Very High Very High Very High
Soft Tissue Injuries 22 98.44 Very High Very High Very High
Coma 44 97.20 Very High Very High Very High
Diffuse Axonal Injury 11 94.92 High High
Head Trauma 55 94.88 High High
Cv General 4 Under Development 33 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A larger group of patients needs to be studied to determine the impact of individual brain pathology on outcomes and BIS and StcO2 values.
Regulation (values) of StcO2 in brain associated with brain disease
1) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.17
There are 1,883 concurrent, hourly observations of ICP, CPP, BIS and StcO2 values.
Regulation (values) of StcO2 associated with cva
2) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.77 Pain Relevance 0.30
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Regulation (values) of StcO2 associated with injury and cva
3) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
The study purpose is to determine the relationships between StcO2 and BIS values in severe brain injury and ICU outcomes (survival, discharge Glasgow Coma Scale (GCS) score, ICP, CPP, and interventions to lower ICP).


Spec (determine) Regulation (values) of StcO2 in brain associated with cva, coma and brain injury
4) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.40
Surviving patients and patients with good neurological outcome have higher BIS and StcO2 values.
Regulation (values) of StcO2
5) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.55
The hourly StcO2 and BIS values did not influence treatment decisions.
Neg (not) Regulation (values) of StcO2
6) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.44 Pain Relevance 0.08
Key messages

• Noninvasive BIS and StcO2 values are clinically relevant with severe brain injury. • ICP, BIS, and StcO2 values provide complementary information. • When ICP increases or CPP decreases, there is cerebral hypoxia and altered brain wave patterns. • Future studies will determine the therapeutic and diagnostic benefit of BIS and StcO2 monitoring. • CAP Index is a discriminate relationship between ICP and MAP that has prognostic and therapeutic implications.


Regulation (values) of StcO2 in brain associated with cerebral hypoxia, cva and brain injury
7) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.41 Pain Relevance 0.50
These outcomes need to be compared with post-injury BIS and StcO2 values.
Regulation (values) of StcO2 associated with injury
8) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.24 Pain Relevance 0.17
Severe forehead, soft tissue injury may prohibit BIS or cerebral oximetry sensor application or alter the BIS or StcO2 values.
Regulation (values) of StcO2 associated with soft tissue injuries
9) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.02 Pain Relevance 0.33
Bilateral frontal lobe contusions may alter the StcO2 values, thus impeding their clinical interpretation.
Spec (may) Regulation (alter) of StcO2 in lobe associated with contusions
10) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.00 Pain Relevance 0.32
Prospective trials need to be performed to assess the hour-to-hour treatment implications of BIS and StcO2 values.
Regulation (values) of StcO2
11) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.22 Pain Relevance 0.21

General Comments

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