INT203

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2011
Negated 16
Speculated 5
Reported most in Abstract
Documents 257
Total Number 266
Disease Relevance 90.56
Pain Relevance 92.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
plasma 63
pituitary 9
melanocyte 8
hypothalamus 8
brain 6
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 228 100.00 Very High Very High Very High
Morphine 169 100.00 Very High Very High Very High
medulla 167 100.00 Very High Very High Very High
Enkephalin 122 100.00 Very High Very High Very High
opiate 93 100.00 Very High Very High Very High
analgesia 76 100.00 Very High Very High Very High
opioid receptor 65 100.00 Very High Very High Very High
Dynorphin 56 100.00 Very High Very High Very High
antinociception 12 100.00 Very High Very High Very High
antagonist 363 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1460 100.00 Very High Very High Very High
Hypoglycemia 29 100.00 Very High Very High Very High
Spontaneous Abortion 6 99.98 Very High Very High Very High
Pain 203 99.96 Very High Very High Very High
Rheumatoid Arthritis 29 99.96 Very High Very High Very High
Glycosuria 1 99.96 Very High Very High Very High
Hyperplasia 40 99.88 Very High Very High Very High
Body Weight 217 99.86 Very High Very High Very High
Nicotine Addiction 3 99.82 Very High Very High Very High
Herpes Simplex Virus 11 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems likely that upregulation of the POMC gene precedes acrylamide-induced neuropathy.
Spec (likely) Positive_regulation (upregulation) of POMC gene associated with induced neuropathy and neuropathic pain
1) Confidence 0.70 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15003292 Disease Relevance 0.10 Pain Relevance 0.10
Upregulation of the pro-opiomelanocortin gene in motoneurones after acrylamide administration in mice.
Positive_regulation (Upregulation) of pro-opiomelanocortin
2) Confidence 0.70 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15003292 Disease Relevance 0 Pain Relevance 0.08
Clinical studies show a disproportion of POMC cleavage products in the CSF of chronic alcoholics (reduced beta-endorphin versus increased ACTH contents), together with remarkable indications for baseline differences in beta-endorphin levels.
Positive_regulation (increased) of ACTH in cleavage
3) Confidence 0.70 Published 1988 Journal Alcohol Section Abstract Doc Link 2969250 Disease Relevance 0.16 Pain Relevance 0.32
In the hypothalamus beta-endorphin level increased after 72-h food deprivation only.
Positive_regulation (increased) of beta-endorphin in hypothalamus
4) Confidence 0.70 Published 1985 Journal Arch. Int. Physiol. Biochim. Section Abstract Doc Link 2421664 Disease Relevance 0.25 Pain Relevance 0.56
Furthermore, serum level of beta-endorphin was increased (P < 0.01) after propofol injection particularly at the peak time of propofol action.
Positive_regulation (increased) of beta-endorphin
5) Confidence 0.70 Published 1998 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 9773504 Disease Relevance 0.63 Pain Relevance 0.92
Furthermore, EA treatment effectively increased the concentration of beta endorphin in blood and brain of mice more than tumor control as well as normal group.
Positive_regulation (increased) of beta endorphin in blood associated with cancer
6) Confidence 0.70 Published 2009 Journal Acupunct Electrother Res Section Abstract Doc Link 19711773 Disease Relevance 1.27 Pain Relevance 1.12
A two-fold and five-fold increase in beta-endorphin levels in ob/ob versus lean mice were found in the ventromedial and dorsomedial hypothalamic nuclei respectively.
Positive_regulation (increase) of beta-endorphin
7) Confidence 0.70 Published 1991 Journal Brain Res. Section Abstract Doc Link 1681994 Disease Relevance 0.24 Pain Relevance 0.29
In the immunoblot and immunohistochemical study, the increase of beta-endorphin was observed in the arcuate nucleus of the hypothalamus.
Positive_regulation (increase) of beta-endorphin in hypothalamus
8) Confidence 0.70 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.56
Concomitant to the decrease of withdrawal behavior, there was a significant increase of brain beta-endorphin level in the acupunctured animals.
Positive_regulation (increase) of beta-endorphin in brain associated with withdrawal
9) Confidence 0.70 Published 1979 Journal Am. J. Chin. Med. Section Abstract Doc Link 574354 Disease Relevance 0 Pain Relevance 0.56
Intraperitoneal administration of mexiletine at a dose of 17.5 mg kg(-1) (but not 10.0 mg kg(-1)) caused significant increase in beta-endorphin levels in the mid brain and hypothalamus of HSV-inoculated mice.
Positive_regulation (increase) of beta-endorphin in brain associated with cold sores and mexiletine
10) Confidence 0.70 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14607018 Disease Relevance 1.21 Pain Relevance 0.86
To determine with greater precision the molecular nature of the polypeptide that accounts for the increase in beta-endorphin immunoreactivity, the various molecular forms of beta-endorphin immunoreactivity were resolved by Biogel P-30 column chromatography.
Positive_regulation (increase) of beta-endorphin
11) Confidence 0.70 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6264037 Disease Relevance 0.31 Pain Relevance 0.07
In contrast, POMC mRNA levels were increased by 79% in the hypothalamus of the TK+/+ mice with pituitary POMC cell ablation.
Positive_regulation (increased) of POMC mRNA in hypothalamus
12) Confidence 0.70 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578531 Disease Relevance 0.29 Pain Relevance 0.33
CRH or virus induce ACTH 1-39 and beta-END, whereas inductions with LPS yield major products of ACTH 1-22 to 1-26 and gamma-END, products that are for the most part unique to the immune system.
Positive_regulation (induce) of ACTH in immune system
13) Confidence 0.69 Published 1991 Journal Circ. Shock Section Abstract Doc Link 1663842 Disease Relevance 0.22 Pain Relevance 0.08
Thus, although hypothalamic beta-endorphin system activity in human and animal models of alcoholism differs under basal conditions, there is enhanced hypothalamic beta-endorphin system activity after exposure to ethanol in both models.
Positive_regulation (enhanced) of beta-endorphin associated with alcohol addiction
14) Confidence 0.69 Published 1996 Journal Alcohol Alcohol. Section Abstract Doc Link 8736999 Disease Relevance 0.24 Pain Relevance 0.48
Thus, although hypothalamic beta-endorphin system activity in human and animal models of alcoholism differs under basal conditions, there is enhanced hypothalamic beta-endorphin system activity after exposure to ethanol in both models.
Positive_regulation (enhanced) of beta-endorphin associated with alcohol addiction
15) Confidence 0.69 Published 1996 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 9845036 Disease Relevance 0.24 Pain Relevance 0.48
We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E2 (PGE2) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT.
Positive_regulation (increasing) of beta-endorphin in PGE2 associated with analgesic
16) Confidence 0.69 Published 1994 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8165365 Disease Relevance 0.06 Pain Relevance 0.20
These results suggest that the anti-aversive effects of SCT may be mediated, at least in part, by the activation of ACTH.
Positive_regulation (activation) of ACTH
17) Confidence 0.69 Published 1994 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8165365 Disease Relevance 0.09 Pain Relevance 0.19
Intraperitoneal (i.p.) injections of acetic acid increased, but not significantly, the levels of plasma ACTH and PGE2, but not beta-endorphin, which are considered to be psychoneuroendocrines correlated with pain.
Positive_regulation (increased) of beta-endorphin in PGE2 associated with pain
18) Confidence 0.69 Published 1994 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8165365 Disease Relevance 0.10 Pain Relevance 0.23
We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E2 (PGE2) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT.
Positive_regulation (increasing) of ACTH in PGE2 associated with analgesic
19) Confidence 0.69 Published 1994 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8165365 Disease Relevance 0.05 Pain Relevance 0.19
In contrast, basal plasma levels of ACTH (20.0 +/- 9.5 pg/ml----352.8 +/- 150.8 pg/ml) were elevated in all patients.
Positive_regulation (elevated) of ACTH in plasma
20) Confidence 0.69 Published 1985 Journal Anasth Intensivther Notfallmed Section Abstract Doc Link 2994513 Disease Relevance 0 Pain Relevance 0.17

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