INT203041

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.61
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD274, PDCD1LG2) cell proliferation (CD274) signal transduction (CD274)
extracellular region (PDCD1LG2) molecular_function (PDCD1LG2)
Anatomy Link Frequency
B cells 2
CD274 (Homo sapiens)
PDCD1LG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 6 95.36 Very High Very High Very High
rheumatoid arthritis 22 71.60 Quite High
spinal inflammation 90 57.80 Quite High
Inflammation 4 29.72 Quite Low
psoriasis 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 30 81.44 Quite High
Rheumatoid Arthritis 22 71.60 Quite High
Renal Disease 4 70.64 Quite High
Apoptosis 6 62.08 Quite High
Seronegative Spondarthritis 102 57.80 Quite High
Disease 16 46.56 Quite Low
INFLAMMATION 2 29.72 Quite Low
Autoimmune Disease 6 12.16 Low Low
Uveitis 6 5.00 Very Low Very Low Very Low
Psoriasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cytoplasmic immunoreceptor tyrosine-based inhibitory motif of PD-1 was activated by an interaction between PD-1 and its corresponding ligands, PDL-1 (B7-H1) and PDL-2 (B7-DC) [15,16], which induces the inhibitory signal to inhibit the proliferation of T and B cells to maintain peripheral tolerance [14-16].
PDL-1 Binding (interaction) of B7-DC in B cells associated with tolerance
1) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.81 Pain Relevance 0.29
The cytoplasmic immunoreceptor tyrosine-based inhibitory motif of PD-1 was activated by an interaction between PD-1 and its corresponding ligands, PDL-1 (B7-H1) and PDL-2 (B7-DC) [15,16], which induces the inhibitory signal to inhibit the proliferation of T and B cells to maintain peripheral tolerance [14-16].
PDL-1 Binding (interaction) of PDL-2 in B cells associated with tolerance
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794506 Disease Relevance 0.81 Pain Relevance 0.29

General Comments

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