INT203169

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
plasma membrane (PTGER2) signal transducer activity (PTGER2) cytoplasm (CPOX)
CPOX (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 6 96.92 Very High Very High Very High
Osteoarthritis 105 95.40 Very High Very High Very High
Inflammation 15 17.84 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 106 95.40 Very High Very High Very High
INFLAMMATION 19 17.84 Low Low
Burns 5 6.40 Low Low
Erythema 9 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Osteoporosis 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to further investigate the involvement of the two COX isoforms in PGE2 production in EM, indomethacin (a non-selective COX inhibitor) and NS-398 (a selective COX-2 inhibitor) were employed.
COX Spec (investigate) Regulation (involvement) of Gene_expression (production) of PGE2 associated with cox-2 inhibitor
1) Confidence 0.00 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.05
and 1,25(OH)2D3 on PGE2 production was reflected by a similar effect on COX-2 synthesis responsible for PGE2 production (Figure 6, bottom panel).
COX Regulation (responsible) of Gene_expression (production) of PGE2
2) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.48 Pain Relevance 0.24

General Comments

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