INT203478

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.15
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Crebbp) nucleus (Crebbp) DNA binding (Crebbp)
protein complex (Crebbp) transcription factor binding (Crebbp) cytoplasm (Crebbp)
Crebbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 129 96.84 Very High Very High Very High
Inflammatory response 19 86.28 High High
trigeminal ganglion 66 60.48 Quite High
withdrawal 12 52.24 Quite High
Spinal cord 3 31.28 Quite Low
aspirin 2 22.72 Low Low
cOX1 1 19.92 Low Low
COX2 1 19.20 Low Low
addiction 12 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 98.72 Very High Very High Very High
INFLAMMATION 88 96.84 Very High Very High Very High
Cirrhosis 6 91.40 High High
Cardiovascular Disease 1 88.96 High High
Hyperglycemia 2 83.40 Quite High
Targeted Disruption 37 74.64 Quite High
Diabetes Mellitus 2 72.88 Quite High
Hypertension 1 72.48 Quite High
Prostate Cancer 80 71.80 Quite High
Ganglion Cysts 70 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast with our results, Comuzzi et al. have suggested that CBP expression is down-regulated after treating LNCaP cells with synthetic androgen methyltrienolone (R1881) for 48 hours at concentrations of 0.01 nM and 1 nM [29].
Gene_expression (expression) of CBP
1) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.06 Pain Relevance 0
Similarly, the expression of MAK, CBP, and BRCA1 was increased more in LNCaP-ARhi than in LNCaP-pcDNA3.1, and, at least, a 10-fold sensitization was observed.
Gene_expression (expression) of CBP
2) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.14 Pain Relevance 0.03
However, induction of expression in lower concentrations of DHT in LNCaP-ARhi compared to LNCaP-pcDNA3.1 was found in MAK, CBP, AIB1, and BRCA1.
Gene_expression (found) of CBP
3) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0
However, overexpression of AR enhanced the DHT-stimulated expression of MAK, BRCA1, AIB1 and CBP and reduced the level of expression of ?
Gene_expression (expression) of CBP
4) Confidence 0.35 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2518564 Disease Relevance 0.11 Pain Relevance 0
B, AP-1, C/EBPs), while others have been newly identified in the present study (CBP, HNF4?
Gene_expression (present) of CBP
5) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.23 Pain Relevance 0.39
Transcriptional repressor functions have been described for the Hox genes [35], and there is evidence that Hox proteins can directly block the activity of the widely expressed histone acetyltransferase CBP-p300 [36].
Gene_expression (expressed) of histone acetyltransferase CBP-p300
6) Confidence 0.02 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.61 Pain Relevance 0.03

General Comments

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