INT203499

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Isl2) intracellular (Isl2) DNA binding (Isl2)
Anatomy Link Frequency
sensory neurons 1
neurons 1
ventral 1
Isl2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 207 98.90 Very High Very High Very High
Central nervous system 13 86.64 High High
midbrain 4 63.76 Quite High
nociceptor 32 58.04 Quite High
Neurotransmitter 7 53.20 Quite High
cerebral cortex 2 25.40 Quite Low
Spinal cord 10 24.20 Low Low
calcitonin gene related peptide 11 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 225 98.90 Very High Very High Very High
Targeted Disruption 85 92.40 High High
Death 2 66.12 Quite High
Neurodegenerative Disease 15 59.52 Quite High
Repression 15 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Isl2 in ventral
1) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
In both the DRG and the TG, this intermediate-sized and later-developing population of Etv1-expressing sensory neurons could be further distinguished from the 1a proprioceptors by the co-expression of Islet2 (Figure 2e, f).
Gene_expression (expression) of Islet2 in sensory neurons associated with trigeminal ganglion
2) Confidence 0.04 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.51 Pain Relevance 0.33
Etv1-expressing neurons that develop in the TG by E16.5 are distinguished by smaller size and the co-expression of Islet2, and appear to represent a distinct subset of sensory neurons.
Gene_expression (expression) of Islet2 in neurons associated with trigeminal ganglion
3) Confidence 0.04 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.50 Pain Relevance 0.20
These cells were negative for TrkC (Figure 2C) but co-expressed Islet2 (Figure 2E), which together with their small size suggests that they are not proprioceptors.
Gene_expression (expressed) of Islet2
4) Confidence 0.02 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.76 Pain Relevance 0.15

General Comments

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