INT20378

From wiki-pain
Revision as of 12:16, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 41.96
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
T cells 6
macrophages 5
Th1 cells 5
Th17 cells 3
lymphocytes 2
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1116 100.00 Very High Very High Very High
Inflammation 1028 100.00 Very High Very High Very High
chemokine 416 99.96 Very High Very High Very High
rheumatoid arthritis 628 99.92 Very High Very High Very High
Enkephalin 2 99.22 Very High Very High Very High
Central nervous system 284 99.14 Very High Very High Very High
Multiple sclerosis 609 98.26 Very High Very High Very High
Arthritis 396 96.52 Very High Very High Very High
Crohn's disease 54 96.52 Very High Very High Very High
psoriasis 368 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1173 100.00 Very High Very High Very High
INFLAMMATION 1094 100.00 Very High Very High Very High
Immunization 192 100.00 Very High Very High Very High
Bacterial Meningitis 15 100.00 Very High Very High Very High
Rheumatoid Arthritis 635 99.92 Very High Very High Very High
Pneumococcal Infection 21 99.78 Very High Very High Very High
Cancer 349 99.60 Very High Very High Very High
Multiple Sclerosis 933 99.58 Very High Very High Very High
Gastritis 59 99.48 Very High Very High Very High
Chlamydia Infection 77 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inasmuch as many Th1/Th2 functions are cytokine mediated, the striking similarity of the Th1 and CD8+ cytokine secretion patterns helps to explain why these two cell types share certain functions such as DTH, and also suggests that further common functions may be discovered in the future.
Localization (secretion) of Th1 associated with cytokine
1) Confidence 0.71 Published 1990 Journal J. Immunol. Section Abstract Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.21
Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.
Localization (secrete) of Th1 in T cell associated with enkephalin and cytokine
2) Confidence 0.55 Published 1990 Journal J. Immunol. Section Title Doc Link 2137843 Disease Relevance 0 Pain Relevance 0.29
As oxazolone-induced colitis is a representative Th2 cell-mediated process, we compared Th1 and Th2 cytokine secretion by CD4+ T cell from CIIT-Tg mice and wild type littermates.
Localization (secretion) of Th1 in T cell associated with colitis and cytokine
3) Confidence 0.50 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.68 Pain Relevance 0.16
C3H/HeN mice responded with both Th1- and Th2-type cytokine secretion, although apparently Th1-skewed due to low IL-4 and IL-10 levels, after both OVA or PSP treatments.
Localization (secretion) of Th1 in PSP associated with cytokine
4) Confidence 0.48 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.28 Pain Relevance 0.28
secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under the Th2 condition (13).
Localization (secretion) of Th1
5) Confidence 0.44 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.43 Pain Relevance 0.07
concentrations were reduced in splenocytes isolated from pBTLA treated mice when stimulated in vitro, indicating that pBTLA treated mice had a reduced Th1 immune response.
Localization (response) of Th1
6) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.30 Pain Relevance 0.13
The isotype profiles were similar to the pre-challenge data, maintaining the observed skewed responses toward Th2 for the MN immunization and Th1 for the IM immunization (Figure 5C, D).


Localization (immunization) of Th1 associated with immunization
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.49 Pain Relevance 0.09
TH1 cytokine secretion is increased after administration of rAAV-/rAdv-hTERTC27
Localization (secretion) of TH1 associated with cytokine
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.33 Pain Relevance 0.23
With regard to the immune response, MS has long been considered to be mediated by myelin protein-specific CD4+ T lymphocytes secreting T helper 1 (Th1) type cytokines such as interferon gamma (IFN?)
Localization (secreting) of Th1 in T lymphocytes associated with multiple sclerosis and cytokine
9) Confidence 0.39 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 2.11 Pain Relevance 0.80
The pBTLA treated mice showed a lower Th1 immune response
Localization (response) of Th1
10) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.62 Pain Relevance 0.08
It seems likely, since B/WF1 mice administrated with plasmid containing many CpG motifs [71], which promote lupus [47], may interact and stimulate a variety of immune cells, and then those cells may secrete mainly Th1 (IFN-?)
Localization (secrete) of Th1 in immune cells associated with systemic lupus erythematosus
11) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.54 Pain Relevance 0.09
antibody IgG1 response (PWT and P22W), while others induced an IgG2a response, such as PDM, PFDM and P24M (Figure 8); this can be compared to PWT and PDM with adjuvant vaccine, which induced a significant Th1 response (Figure 9).
Localization (response) of Th1
12) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.40 Pain Relevance 0.34
Peptides that induced spleen-derived CD4+ T cells to secrete high levels of Th1 (IFN-?
Localization (secrete) of Th1 in T cells
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.40 Pain Relevance 0.09
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of TH1 in macrophages associated with chemokine, multiple sclerosis and central nervous system
14) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.07 Pain Relevance 0.23
Strikingly, treatment of microglia with a combination of granulocyte macrophage-colony stimulating factor and CD40L has been shown to promote differentiation of these cells into cells that (1) express the pan-DC marker CD11c, (2) morphologically resemble DCs, and (3) secrete the Th1-promoting cytokine IL-12 p70 [58].
Localization (secrete) of Th1 in macrophage associated with cytokine
15) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.70 Pain Relevance 0.20
It is well established that IL-12 drives Th1 differentiation and subsequent IFN-?
Localization (differentiation) of Th1
16) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.89 Pain Relevance 0.20
Th1 cells frequently secrete TNF-?.
Localization (secrete) of Th1 in Th1 cells
17) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.98 Pain Relevance 0.16
Mice primed to mount Th2 cell responses followed by pneumococcal infection showed an increase in the number of Pneumococci and an increase in sinus inflammation than compared to naive or Th1 -primed groups [56].
Localization (increase) of Th1 in sinus associated with bacterial meningitis, pneumococcal infection and inflammation
18) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.79 Pain Relevance 0.21
In EAE, auto-reactive CD4+ TH1 cells secrete pro-inflammatory cytokines such as IFN?
Localization (secrete) of TH1 associated with multiple sclerosis, inflammation and cytokine
19) Confidence 0.28 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 1.37 Pain Relevance 0.59
MOMP-vaults significantly increased the secretion of a cytokine needed for production of Th1 cells (IL-12p70) compared to empty vaults or the positive control, lipopolysaccharide (LPS) (Fig. 3a).
Localization (secretion) of Th1 in Th1 cells associated with cytokine
20) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox