INT2039

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Context Info
Confidence 0.60
First Reported 1977
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 30
Total Number 36
Disease Relevance 7.75
Pain Relevance 6.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
fat 2
1A2 2
liver 1
hepatocyte 1
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 27 100.00 Very High Very High Very High
cytokine 7 100.00 Very High Very High Very High
methadone 4 99.20 Very High Very High Very High
Inflammation 53 98.82 Very High Very High Very High
lidocaine 4 98.72 Very High Very High Very High
cINOD 6 97.56 Very High Very High Very High
Onset of action 1 96.96 Very High Very High Very High
Morphine 21 96.68 Very High Very High Very High
sSRI 7 96.16 Very High Very High Very High
Serotonin 5 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 31 100.00 Very High Very High Very High
Cancer 124 99.52 Very High Very High Very High
Fatty Liver 63 99.52 Very High Very High Very High
Sepsis 2 99.34 Very High Very High Very High
INFLAMMATION 55 98.82 Very High Very High Very High
Toxicity 22 98.64 Very High Very High Very High
Prostate Cancer 7 98.28 Very High Very High Very High
Adverse Drug Reaction 4 97.72 Very High Very High Very High
Obesity 19 97.08 Very High Very High Very High
Porphyria 8 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of individual P-450 enzymes is a complex subject, with examples of induction and direct inhibition and stimulation.
Regulation (regulation) of P-450
1) Confidence 0.60 Published 1995 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 7879733 Disease Relevance 0.33 Pain Relevance 0.05
Measurement of the urinary 6beta-hydroxycortisol/cortisol ratio indicated that bevirimat did not affect cytochrome P450 3A activity.
Neg (not) Regulation (affect) of P450
2) Confidence 0.60 Published 2007 Journal Clin Pharmacokinet Section Body Doc Link 17596104 Disease Relevance 0 Pain Relevance 0
In this study, the effects of nine flavonoids on acetaminophen (APAP) oxidation and related cytochrome P450 (P450) enzyme activities were investigated.
Spec (investigated) Regulation (effects) of P450 associated with paracetamol
3) Confidence 0.60 Published 1994 Journal Drug Metab. Dispos. Section Abstract Doc Link 7956731 Disease Relevance 0 Pain Relevance 0.57
Such combinations create the potential for pharmacokinetic interactions by affecting the activity of the cytochromes P450 (CYP450), drug metabolizing oxidative enzymes.
Regulation (affecting) of P450
4) Confidence 0.60 Published 1999 Journal Int Clin Psychopharmacol Section Abstract Doc Link 10471171 Disease Relevance 0 Pain Relevance 0.45
We have studied the effect of a cytochrome P-450 1A2 inhibitor, ciprofloxacin, on the pharmacokinetics of lidocaine.
Regulation (effect) of P-450 in 1A2 associated with lidocaine
5) Confidence 0.44 Published 2005 Journal Eur J Anaesthesiol Section Abstract Doc Link 16211753 Disease Relevance 0 Pain Relevance 0.27
Cytochrome P-450 3A4 is the main enzyme responsible for imatinib metabolism.
Regulation (responsible) of P-450
6) Confidence 0.44 Published 2002 Journal Clin. Cancer Res. Section Body Doc Link 12006504 Disease Relevance 0 Pain Relevance 0
Several inflammatory cytokines, such as interleukins, transforming growth factor beta1, human hepatocyte growth factor, and lymphotoxin, downregulate gene expression of major cytochrome P-450 enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity observed with a given cytokine varying for each P-450 studied, thus eventually leading to metabolite-mediated adverse drug reactions and immunometallic diseases which sometimes result in tissue injury beyond the site(s) where metabolic bioactivation takes place.
Regulation (effects) of P-450 in hepatocyte associated with adverse drug reaction, inflammation, injury, disease and cytokine
7) Confidence 0.44 Published 2002 Journal Am J Ther Section Abstract Doc Link 11897929 Disease Relevance 1.49 Pain Relevance 0.41
The cytochrome (CYP) P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4 are mainly responsible for its metabolism.
Regulation (responsible) of P450
8) Confidence 0.44 Published 2001 Journal CNS Drug Rev Section Abstract Doc Link 11607047 Disease Relevance 0.29 Pain Relevance 0.28
In-vitro data indicate major effects of the genetically polymorphic cytochrome P450 enzyme 2C9 (CYP2C9) on the pharmacokinetics of celecoxib, a nonsteroidal anti-inflammatory drug acting as selective cyclooxygenase-2 inhibitor.
Regulation (effects) of P450 associated with inflammation and cinod
9) Confidence 0.44 Published 2003 Journal Pharmacogenetics Section Abstract Doc Link 12893985 Disease Relevance 0.10 Pain Relevance 0.10
Antibody inhibition experiments indicated that ethoxyresorufin and methoxyresorufin O-dealkylations were catalysed mainly by the P450 1A subfamily in untreated and BA-induced HepG2 cells, that additional unidentified P450 forms were considerably involved in methoxyresorufin and benzyloxyresorufin O-dealkylations and that the P450 2B subfamily was partially responsible for pentoxyresorufin O-dealkylation in PB-induced cells.
Spec (partially) Regulation (responsible) of P450
10) Confidence 0.44 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8395842 Disease Relevance 0.15 Pain Relevance 0.13
Drug metabolism is dependent on function of the cytochrome P450 enzymes, such as 2D6 and 3A4.
Regulation (dependent) of P450
11) Confidence 0.44 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17620087 Disease Relevance 0.17 Pain Relevance 0.22
BACKGROUND: The aim of this study was to investigate the effects of the cytochrome P450 3A4 (CYP34A) inhibitor itraconazole on the pharmacokinetics and pharmacodynamics of orally and intravenously administered oxycodone.
Spec (investigate) Regulation (effects) of P450 associated with oxycodone
12) Confidence 0.44 Published 2010 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 20076952 Disease Relevance 0 Pain Relevance 0.17
To address this issue, we investigated the effects of P450 inhibitors (cimetidine, sulfaphenazole, erythromycin, nifedipine, and ketoconazole) on the UGT2B7-catalyzed formation of morphine-3-glucuronide (M-3-G) and morphine-6-glucuronide (M-6-G).
Spec (investigated) Regulation (effects) of P450 associated with morphine
13) Confidence 0.40 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679387 Disease Relevance 0 Pain Relevance 0.40
OBJECTIVE: A series of studies was undertaken to determine the cytochrome P450 isoform(s) involved in naproxen demethylation and whether this included the same isoforms reported to be involved in the metabolism of other NSAIDs.
Spec (determine) Regulation (determine) of P450 associated with cinod
14) Confidence 0.39 Published 1997 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 9248768 Disease Relevance 0 Pain Relevance 0.09
We aimed to determine the influence of CYP2B6, CYP2C9, and CYP2C19 genetic polymorphism on methadone pharmacokinetics and on the response to treatment.
Spec (determine) Regulation (influence) of CYP2B6 associated with methadone
15) Confidence 0.30 Published 2005 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 16338275 Disease Relevance 0 Pain Relevance 0.27
Fats, proteins, and nonnutrients such as flavones, antioxidants, and contaminants like DDT all affect P-450 levels.
Regulation (affect) of P-450 in Fats
16) Confidence 0.30 Published 1977 Journal Fed. Proc. Section Abstract Doc Link 321252 Disease Relevance 0.47 Pain Relevance 0.08
This study provides the first evidence that P450 is not only involved in oxidation of drugs but also modulates the function of UGTs.
Regulation (modulates) of P450
17) Confidence 0.27 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15611481 Disease Relevance 0 Pain Relevance 0.42
Insights into the structure, function, and regulation of human cytochrome P450 1A2.
Regulation (regulation) of P450 in 1A2
18) Confidence 0.26 Published 2009 Journal Curr. Drug Metab. Section Title Doc Link 19702529 Disease Relevance 0 Pain Relevance 0.14
Oxycodone has clinically significant drug interactions with drugs affecting cytochrome P450 3A enzymes.
Regulation (affecting) of P450
19) Confidence 0.26 Published 2009 Journal Curr Opin Anaesthesiol Section Body Doc Link 19369865 Disease Relevance 0 Pain Relevance 0
Some of the foodstuffs and conditions that influence P-450 in experimental animals and in humans are protein, carbohydrate, lipid, obesity and fasting, water- and fat-soluble vitamins, minerals, sulfides, isothiocyanates, indoles, ellagic acid, capsaicin, terpenes, flavones, butylated hydroxytoluene and hydroxyanisole, charbroiled foods, ethanol, and (monosodium) glutamate and aspartate.
Regulation (influence) of P-450 in fat associated with glutamate, qutenza and obesity
20) Confidence 0.26 Published 1995 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 7879733 Disease Relevance 0.37 Pain Relevance 0.14

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