INT20393

Context Info Confidence 0.03 First Reported 1990 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.07

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1) signal transducer activity (FPR1)

FPR1 (Homo sapiens) CR1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 65.08

Disease Link Frequency Relevance Heat INFLAMMATION 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We conclude that piroxicam and indomethacin inhibit FMLP receptor-mediated upregulation of CD11b, CD11c, and CD35 in PMNs, but have no effect on the upregulation of these molecules by ionomycin or C5a.

Negative_regulation (inhibit) of FMLP Positive_regulation (upregulation) of CD35

1) Confidence 0.03 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

This test has worked.