INT20397

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 6.48
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgax)
Anatomy Mention Frequency
marginal zone 1
B cells 1
myeloid cells 1
platelets 1
DEC-205 1
Itgax (Mus musculus)
Pain Term Frequency Confidence Heat
Inflammation 98 97.28 Very High Very High Very High
cINOD 11 95.28 Very High Very High Very High
Angina 2 93.44 High High
glial activation 3 92.96 High High
vincristine 5 91.48 High High
Central nervous system 37 84.24 Quite High
metalloproteinase 9 83.80 Quite High
cytokine 101 79.08 Quite High
antagonist 3 75.00 Quite High
chemokine 34 37.96 Quite Low
Disease Term Frequency Confidence Heat
Adhesions 22 100.00 Very High Very High Very High
Lymphatic System Cancer 57 99.98 Very High Very High Very High
Hypothermia 55 99.70 Very High Very High Very High
INFLAMMATION 136 99.68 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Leukemia 6 98.44 Very High Very High Very High
Infection 84 96.60 Very High Very High Very High
Respiratory Syncytial Virus 62 96.20 Very High Very High Very High
Neuropathic Pain 1 94.96 High High
Cv General 3 Under Development 4 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all of these organs small increases in CD11c+ CD8+ T cells were detected from dpi 4 onwards but their percentage returned to baseline rapidly.
Positive_regulation (increases) of CD11c in T cells
1) Confidence 0.46 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 1.13 Pain Relevance 0
In contrast, infiltrating CD11b and CD11c positive myeloid cells predominantly produced TLR11 protein, particularly early during infection at 1 wk post infection (~50% cells).
Positive_regulation (infiltrating) of CD11c in myeloid cells associated with infection
2) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2631477 Disease Relevance 0.54 Pain Relevance 0.11
Hypothermia (27°C) delays upregulation of Mac-1 and CD11c, but has no effect on LFA-1 [174,176].
Positive_regulation (upregulation) of CD11c associated with hypothermia
3) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.97 Pain Relevance 0.09
For FACS analysis, the following monoclonal antibodies were used: I-A/I-E, CD80, CD86, CD11c, and DEC-205.
Positive_regulation (used) of CD11c in DEC-205
4) Confidence 0.12 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 0.40 Pain Relevance 0
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of CD11C in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
5) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0
Nonsteroidal antiinflammatory agents inhibit upregulation of CD11b, CD11c, and CD35 in neutrophils stimulated by formyl-methionine-leucine-phenylalanine.
Positive_regulation (upregulation) of CD11c in neutrophils associated with inflammation
6) Confidence 0.10 Published 1990 Journal Inflammation Section Title Doc Link 2138999 Disease Relevance 0.20 Pain Relevance 0.17
Furthermore, piroxicam had no effect on 37 degrees C-induced upregulation of any of the surface proteins, while indomethacin showed no effect on 37 degrees C-induced CD11b upregulation but suppressed CD11c and CD35 upregulation.
Positive_regulation (upregulation) of CD11c
7) Confidence 0.10 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.13 Pain Relevance 0.13
Phenotypic analysis by flow cytometric analysis on pre- and post-bryostatin 1-treated peripheral blood lymphocytes revealed up-regulation in the coexpression of CD11c/ CD22 on CD20+ B cells in two of four CLL patients studied, which is consistent with in vitro findings of differentiation of CLL cells to a hairy cell phenotype.
Positive_regulation (up-regulation) of CD11c in B cells associated with leukemia
8) Confidence 0.09 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741703 Disease Relevance 0.63 Pain Relevance 0.21
Both piroxicam and indomethacin inhibited FMLP-induced upregulation of CD11b, CD11c, and CD35, but neither drug affected the upregulation of these surface molecules induced by C5a or ionomycin.
Positive_regulation (upregulation) of CD11c
9) Confidence 0.07 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.14 Pain Relevance 0.16
In addition, cells expressing high levels of molecules involved in antigen presentation such as MHC class II, CD11c, and CD68 were elevated [165].
Positive_regulation (elevated) of CD11c
10) Confidence 0.07 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.50 Pain Relevance 0.13
We conclude that piroxicam and indomethacin inhibit FMLP receptor-mediated upregulation of CD11b, CD11c, and CD35 in PMNs, but have no effect on the upregulation of these molecules by ionomycin or C5a.
Positive_regulation (upregulation) of CD11c
11) Confidence 0.07 Published 1990 Journal Inflammation Section Abstract Doc Link 2138999 Disease Relevance 0.07 Pain Relevance 0.06
Abciximab binds with high avidity to both the non-activated and activated form of the GPIIb/IIIa receptor of platelets, the major adhesion receptor involved in aggregation.
Positive_regulation (activated) of adhesion receptor in platelets associated with adhesions
12) Confidence 0.07 Published 2000 Journal Pathol. Oncol. Res. Section Abstract Doc Link 11033455 Disease Relevance 0.61 Pain Relevance 0.13

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