INT2040

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 95
Total Number 103
Disease Relevance 34.30
Pain Relevance 25.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 8
hepatocytes 5
1A2 4
plasma 3
CAR 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 81 100.00 Very High Very High Very High
methadone 40 100.00 Very High Very High Very High
carbamazepine 49 99.98 Very High Very High Very High
cocaine 296 99.90 Very High Very High Very High
alcohol 79 99.84 Very High Very High Very High
Pain 12 99.84 Very High Very High Very High
Dextromethorphan 18 99.78 Very High Very High Very High
Endep 10 99.78 Very High Very High Very High
Chronic pancreatitis 21 99.76 Very High Very High Very High
anticonvulsant 22 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 40 100.00 Very High Very High Very High
Nicotine Addiction 43 99.98 Very High Very High Very High
Cirrhosis 225 99.92 Very High Very High Very High
Necrosis 59 99.92 Very High Very High Very High
Fatty Liver 415 99.84 Very High Very High Very High
Pancreatitis 35 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 143 99.52 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 183 99.44 Very High Very High Very High
Vomiting 24 99.40 Very High Very High Very High
Diabetes Mellitus 126 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data could explain why the plasma concentration ratio of R/S methadone is variable and why drugs that induce CYP2B6 such as nevirapine and efavirenz also induce methadone metabolism, while the CYP3A4 inducer rifabutin has no effect on methadone pharmacokinetics.
Positive_regulation (induce) of CYP2B6 in plasma associated with methadone
1) Confidence 0.69 Published 2004 Journal Chirality Section Abstract Doc Link 14628297 Disease Relevance 0 Pain Relevance 0.99
P-450 2E1 is induced by alcohol consumption and possibly starvation, and glutathione depletion can occur due to the inadequate nutrition occurring in chronic alcohol use or in starvation.
Spec (possibly) Positive_regulation (induced) of P-450 associated with starvation and alcohol
2) Confidence 0.67 Published 1999 Journal Curr Gastroenterol Rep Section Abstract Doc Link 10980926 Disease Relevance 1.03 Pain Relevance 0.39
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of P450 in placenta associated with nicotine addiction
3) Confidence 0.67 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.58 Pain Relevance 0
The plasma concentration is lower with repeated dosing than predicted from single-dose studies due to induction of the cytochrome p450 3A4 isoform of the liver microsomal enzyme system.
Positive_regulation (induction) of p450 in liver
4) Confidence 0.67 Published 2003 Journal Expert Opin Investig Drugs Section Abstract Doc Link 14585057 Disease Relevance 0.93 Pain Relevance 0.06
Its biphasic evolution, from acinar cell hyperplasia and hyperactivity toward effacement of enzyme as well as bicarbonate secretory parenchyma, would be rationalized if it was linked to induction of cytochrome P450 mono-oxygenases (CYP): the increased oxidant load from long-term CYP induction eventually erodes micronutrient antioxidant defenses to injure cells.
Positive_regulation (induction) of P450 in parenchyma associated with attention deficit hyperactivity disorder and hyperplasia
5) Confidence 0.67 Published 1995 Journal Int. J. Pancreatol. Section Abstract Doc Link 8530827 Disease Relevance 0.53 Pain Relevance 0.30
Omeprazole, a widely used and potent gastric proton pump inhibitor, induces cytochrome P450 (CYP) 1A2 in humans.
Positive_regulation (induces) of P450 in 1A2
6) Confidence 0.67 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9246016 Disease Relevance 0.08 Pain Relevance 0.40
His theophylline clearance of 450 ml/kg/h was several times higher than normal, indicating induction of cytochromes P450.
Positive_regulation (induction) of P450
7) Confidence 0.67 Published 1988 Journal Int. J. Pancreatol. Section Abstract Doc Link 3361161 Disease Relevance 0.27 Pain Relevance 0.36
Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole.
Positive_regulation (induction) of P450
8) Confidence 0.67 Published 2007 Journal Clin. Pharmacol. Ther. Section Title Doc Link 17344806 Disease Relevance 0 Pain Relevance 0.10
Cytochrome P-450 dependent 7-ethoxycoumarin O-deethylase was increased 5-fold. (3) A human hepatoma cell line (Hep G2) was studied to obtain information on the inducibility of human UDP-GT activities by 3-methylcholanthrene-type inducers.
Positive_regulation (increased) of P-450 in Hep G2 associated with hepatocellular cancer
9) Confidence 0.67 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2825716 Disease Relevance 0.10 Pain Relevance 0.19
We argue that these hepatic changes mirror changes in pancreatic-acinar cells and that increased free radical activity in both organs is due to a shortfall of antioxidants in the face of cytochromes P450 induction by xenobiotics.
Positive_regulation (induction) of P450 in face
10) Confidence 0.67 Published 1990 Journal Free Radic. Biol. Med. Section Abstract Doc Link 2379863 Disease Relevance 1.13 Pain Relevance 0.54
John's wort can interact with many medications owing to induction of cytochrome P-450 3A4 and other mechanisms.
Positive_regulation (induction) of P-450
11) Confidence 0.67 Published 2006 Journal J Soc Integr Oncol Section Abstract Doc Link 16737673 Disease Relevance 1.13 Pain Relevance 0.61
Long-term anticonvulsant drug therapy may have a contributory role in the development of chronic pancreatitis by chronic stimulation of cytochromes P-450.
Positive_regulation (stimulation) of cytochromes P-450 associated with anticonvulsant and chronic pancreatitis
12) Confidence 0.60 Published 1992 Journal Ital J Gastroenterol Section Abstract Doc Link 1623223 Disease Relevance 0.36 Pain Relevance 0.36
Animal experiments show that suboptimal intakes of dietary antioxidants and/or excessive intakes of highly unsaturated fatty acids and/or induction of cytochromes P450 facilitate peroxidation of cellular lipid membranes by free radicals.
Positive_regulation (induction) of cytochromes P450
13) Confidence 0.60 Published 1986 Journal Hum Nutr Clin Nutr Section Abstract Doc Link 3957720 Disease Relevance 0.16 Pain Relevance 0.25
Primary human hepatocytes in culture are commonly used to evaluate cytochrome P450 (P450) induction via an enzyme activity endpoint.
Positive_regulation (induction) of P450 in hepatocytes
14) Confidence 0.59 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679385 Disease Relevance 0 Pain Relevance 0.07
Primary human hepatocytes in culture are commonly used to evaluate cytochrome P450 (P450) induction via an enzyme activity endpoint.
Positive_regulation (induction) of P450 in hepatocytes
15) Confidence 0.59 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679385 Disease Relevance 0 Pain Relevance 0.07
Metabolized by several cytochrome P450 (CYP450) enzymes, modafinil is a mild inducer of CYP1A2, CYP2B6, CYP3A4, and is a mild inhibitor of CYP2C19 (Cephalon 2004).
Positive_regulation (inducer) of CYP2B6
16) Confidence 0.59 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654790 Disease Relevance 0.15 Pain Relevance 0.26
Because ropivacaine is an amide-type local anesthetic, it is metabolized by cytochrome P450 (P450) in the liver, and its elimination and plasma concentration can be dependent on the level of P450.
Positive_regulation (dependent) of P450 in plasma associated with local anesthetic
17) Confidence 0.53 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7832304 Disease Relevance 0.09 Pain Relevance 0.35
Pharmacophores were generated for 16 structurally diverse CYP2B6 substrates with Catalyst after overlapping the reaction sites.
Positive_regulation (generated) of CYP2B6
18) Confidence 0.50 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 11744616 Disease Relevance 0 Pain Relevance 0
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.
Positive_regulation (inducers) of P450
19) Confidence 0.49 Published 2008 Journal Curr. Drug Metab. Section Title Doc Link 18473749 Disease Relevance 0.12 Pain Relevance 0.10
It is important to characterise the properties [e.g. substrate and enzyme activity (particularly cytochrome P450 3A4 induction)] of new anticonvulsants and recognise their potential to interfere with OCs.
Positive_regulation (induction) of P450 associated with anticonvulsant
20) Confidence 0.49 Published 2000 Journal Clin Pharmacokinet Section Abstract Doc Link 10803456 Disease Relevance 0.07 Pain Relevance 0.39

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