INT20407

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Context Info
Confidence 0.52
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
DDI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 1 88.92 High High
Pain 2 88.04 High High
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 98.04 Very High Very High Very High
Sprains And Strains 26 92.16 High High
Pancreatitis 1 90.40 High High
Peripheral Neuropathy 1 88.92 High High
Body Weight 1 81.36 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 76.68 Quite High
Syndrome 2 75.36 Quite High
Immunodeficiency 2 75.00 Quite High
Genomic Instability 1 71.28 Quite High
Weight Gain 1 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the maximal tolerated dose, the peak plasma levels of ddI were 6.3 to 9.6 mumol per liter 0.6 to 1 hour after oral administration; the mean plasma half-life was 1.5 hours.
Gene_expression (levels) of ddI in plasma
1) Confidence 0.52 Published 1990 Journal N. Engl. J. Med. Section Abstract Doc Link 2139173 Disease Relevance 1.10 Pain Relevance 0.13
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (expression) of DNA damage-inducible
2) Confidence 0.01 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.35 Pain Relevance 0

General Comments

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