INT204183

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T-cell 4
lymphocyte 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 63 97.80 Very High Very High Very High
tolerance 6 93.20 High High
Multiple sclerosis 1 85.04 High High
cytokine 26 77.88 Quite High
rheumatoid arthritis 53 42.00 Quite Low
Arthritis 13 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 97.80 Very High Very High Very High
Infection 71 90.28 High High
Hypersensitivity 7 89.12 High High
Viremia 4 88.60 High High
Demyelinating Disease 1 85.04 High High
Immunization 1 80.64 Quite High
Alopecia Areata 31 80.52 Quite High
Alopecia 5 78.72 Quite High
Autoimmune Disease 17 72.32 Quite High
Thyroiditis 1 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One particularly interesting CD4+ T-cell subset with regulatory capacity is defined by the constitutive expression of the ?
Negative_regulation (defined) of Negative_regulation (interesting) of CD4 in T-cell
1) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.81 Pain Relevance 0.22
In SHIV infected macaques, viral loads were associated with a greater diminished percentage of CD4 T cells compared to the CD4 T cell depletion observed in SIV infected animals (Fig. 3B).
Negative_regulation (diminished) of Negative_regulation (depletion) of CD4 in T cell
2) Confidence 0.27 Published 2007 Journal Retrovirology Section Body Doc Link PMC1805449 Disease Relevance 0.27 Pain Relevance 0
Mainly a decrease in CD4 to CD8 lymphocyte count from 4:1 to 1:1 occurs.[2] A decrease in intrabulbar CD6 lymphocytes and langerhans cells is noted.
Negative_regulation (decrease) of Negative_regulation (decrease) of CD4 in lymphocyte
3) Confidence 0.23 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002409 Disease Relevance 0.71 Pain Relevance 0

General Comments

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