INT204285

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Apaf1) aging (Apaf1) Golgi apparatus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1) cytosol (Apaf1)
Anatomy Link Frequency
cleavage 1
Apaf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 6 65.68 Quite High
cytokine 1 49.08 Quite Low
Kinase C 21 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 19 98.06 Very High Very High Very High
Injury 10 97.46 Very High Very High Very High
Apoptosis 83 97.44 Very High Very High Very High
Death 54 96.84 Very High Very High Very High
Body Weight 28 83.56 Quite High
Hepatotoxicity 14 64.60 Quite High
Cv General 4 Under Development 1 59.32 Quite High
Hypoxia 2 44.96 Quite Low
Poisoning 9 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As caused mitochondrial injury by increased oxidative stress and reciprocal regulation of Bcl-2, Bcl-xL/Bad, Bax, Bim in association with increased level of Apaf-1, activation of caspase 9/3, cleavage of PARP protein and ultimately led to apoptotic cell death.
Positive_regulation (activation) of Apaf-1 in cleavage associated with stress, injury, apoptosis and death
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.84 Pain Relevance 0
We and others have previously demonstrated that calpains activated during excitotoxicity degrade and inactivate essential components of the caspase activating pathway including APAF-1, procaspase-9, -8, and -3 [8,35,36].
Positive_regulation (activated) of APAF-1
2) Confidence 0.09 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC1808451 Disease Relevance 1.03 Pain Relevance 0.03

General Comments

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