INT204326

Context Info Confidence 0.51 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.19 Pain Relevance 0

nucleus (SIRT1, PPARGC1A) cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1)

SIRT1 (Homo sapiens) PPARGC1A (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 1 83.92 Obesity 11 54.64 Weight Loss 2 54.28 Stress 10 20.04 Aging 8 18.68 Targeted Disruption 1 10.96 Overweight 6 5.00 Chronic Disease 2 5.00 Heart Disease 1 5.00 Helminth Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SIRT1 is known to bind, deacetylate, and activate PPARGC1A, thus promoting mitochondrial biogenesis [11].

SIRT1 Positive_regulation (activate) of PPARGC1A

1) Confidence 0.51 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.19 Pain Relevance 0

General Comments

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