INT204332

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.42
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A)
mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)
Anatomy Link Frequency
body 1
PPARGC1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 1 71.84 Quite High
Intracerebroventricular 1 69.04 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 2 99.36 Very High Very High Very High
Stress 62 98.00 Very High Very High Very High
Overweight 36 97.40 Very High Very High Very High
Aging 51 96.64 Very High Very High Very High
Alzheimer's Dementia 9 84.48 Quite High
Obesity 67 78.60 Quite High
Disease 43 74.20 Quite High
Targeted Disruption 7 74.08 Quite High
Apoptosis 6 70.92 Quite High
Chronic Disease 12 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.
Positive_regulation (increase) of PPARGC1A
1) Confidence 0.67 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0
The mammalian ortholog of Sir2, known as sirtuin 1 (SIRT1), deacetylates and activates PPARGC1A [11,14], suggesting a direct link between SIRT1 and mitochondrial bioenergetics.
Positive_regulation (activates) of PPARGC1A
2) Confidence 0.67 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.19 Pain Relevance 0
In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].
Positive_regulation (increase) of PPARGC1A
3) Confidence 0.67 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.
Positive_regulation (induction) of PPARGC1A in body associated with overweight
4) Confidence 0.49 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0
In line with these studies, resveratrol appears to be protective against the dysregulation of energy homeostasis observed in mouse models for metabolic syndromes by a mechanism implicating the activation of SIRT1, PGC-1?
Positive_regulation (activation) of PGC associated with syndrome
5) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.45 Pain Relevance 0.07
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Positive_regulation (increase) of PPARGC1A
6) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).
Positive_regulation (increased) of PPARGC1A
7) Confidence 0.20 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1808482 Disease Relevance 0.22 Pain Relevance 0

General Comments

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