INT204351

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A)
mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)
Anatomy Link Frequency
body 1
PPARGC1A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 18 96.62 Very High Very High Very High
Stress 30 84.72 Quite High
Apoptosis 3 67.60 Quite High
Targeted Disruption 3 40.64 Quite Low
Obesity 33 38.32 Quite Low
Weight Loss 6 37.96 Quite Low
Body Weight 3 10.68 Low Low
Aging 24 5.00 Very Low Very Low Very Low
Chronic Disease 6 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.
Negative_regulation (decrease) of PPARGC1A in body associated with overweight
1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Negative_regulation (levels) of PPARGC1A
2) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].
Negative_regulation (regulator) of PPARGC1A
3) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0

General Comments

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