INT204351

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.25 Pain Relevance 0

cytosol (PPARGC1A) mRNA processing (PPARGC1A) RNA binding (PPARGC1A) mitochondrion organization (PPARGC1A) nucleus (PPARGC1A) protein complex assembly (PPARGC1A)

Anatomy Link Frequency body 1 PPARGC1A (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 3 5.00

Disease Link Frequency Relevance Heat Overweight 18 96.62 Stress 30 84.72 Apoptosis 3 67.60 Targeted Disruption 3 40.64 Obesity 33 38.32 Weight Loss 6 37.96 Body Weight 3 10.68 Aging 24 5.00 Chronic Disease 6 5.00 Heart Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.

Negative_regulation (decrease) of PPARGC1A in body associated with overweight

1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Negative_regulation (levels) of PPARGC1A

2) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

In support of this concept, SIRT1 mRNA was increased in the CR and CREX groups in proportion to the increase in PPARGC1A mRNA, consistent with the potential role of SIRT1 as a direct regulator of PPARGC1A activity [11,14].

Negative_regulation (regulator) of PPARGC1A

3) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0

General Comments

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