INT204361

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

cell differentiation (SIRT1) nucleoplasm (SIRT1) mitochondrion (SIRT1) nuclear envelope (SIRT1) histone binding (SIRT1) enzyme binding (SIRT1)

Anatomy Link Frequency body 1 SIRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 1 5.00

Disease Link Frequency Relevance Heat Overweight 6 96.36 Stress 10 84.72 Obesity 11 28.00 Aging 8 5.00 Weight Loss 2 5.00 Chronic Disease 2 5.00 Heart Disease 1 5.00 Helminth Infection 1 5.00 Diabetes Mellitus 1 5.00 Targeted Disruption 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show, to our knowledge for the first time, that in overweight nonobese humans, short-term caloric restriction lowers whole-body energy expenditure (metabolic adaptation), in parallel with an induction in mitochondrial biogenesis, PPARGC1A and SIRT1 mRNA, and a decrease in DNA damage.

Negative_regulation (decrease) of SIRT1 in body associated with overweight

1) Confidence 0.42 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.18 Pain Relevance 0

General Comments

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