INT204492

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0

cytoplasm (App, Fmr1) transport (Fmr1) Golgi apparatus (App) extracellular matrix organization (App) DNA binding (App) cell adhesion (App)

App (Mus musculus) Fmr1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 4 5.00 agonist 3 5.00 tetrodotoxin 1 5.00 cerebral cortex 1 5.00 Hippocampus 1 5.00 halothane 1 5.00

Disease Link Frequency Relevance Heat Syndrome 27 90.96 Alzheimer's Dementia 21 50.00 Cognitive Disorder 2 38.40 Tremor 1 29.44 Ataxia 1 28.88 Dementia 1 25.36 Targeted Disruption 41 10.20 Autism 6 7.20 Aggression 1 6.32 Sprains And Strains 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When FMRP is bound to APP or other synaptic mRNAs, translation is repressed.

Negative_regulation (repressed) of APP Binding (bound) of FMRP

1) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.28 Pain Relevance 0

General Comments

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