INT205083

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.51
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUP) cell morphogenesis (JUP) structural molecule activity (JUP)
plasma membrane (JUP) cytoskeleton (JUP) nucleus (JUP)
Anatomy Link Frequency
neural crest 1
acinar cells 1
pancreatic ducts 1
JUP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 12 83.52 Quite High
Kinase C 26 60.08 Quite High
Hippocampus 6 31.88 Quite Low
Inflammation 13 21.20 Low Low
agonist 18 16.96 Low Low
Eae 2 7.12 Low Low
depression 12 6.48 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Nicotine 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 134 100.00 Very High Very High Very High
Cancer 143 96.96 Very High Very High Very High
Familial Adenomatous Polyposis 8 96.80 Very High Very High Very High
Neuroblastoma 50 93.16 High High
Amyloid Plaque 12 91.84 High High
Pancreatic Cancer 54 90.76 High High
Apoptosis 28 88.56 High High
Islet Cell Adenoma 58 88.44 High High
Pheochromocytoma 33 86.72 High High
Targeted Disruption 14 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin in pancreatic adenocarcinomas, with decreased plasma membrane and increased cytoplasmic staining compared to normal pancreatic ducts and acinar cells by immunohistochemistry [46].
Positive_regulation (increased) of catenin in acinar cells associated with adenocarcinoma
1) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.23 Pain Relevance 0
-catenin accumulation, nuclear translocation and Wnt-targeted gene transcription [33].
Positive_regulation (accumulation) of catenin
2) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.19 Pain Relevance 0.04
-catenin, (b) an increase in GSK-3?
Positive_regulation (increase) of catenin
3) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.71 Pain Relevance 0.09
-catenin, resulting in failure of ubiquitination; whereas E-cadherin mutation can cause dissociation of ?
Positive_regulation (cause) of catenin
4) Confidence 0.49 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.32 Pain Relevance 0
This suggests that promoter methylation of CTNNG does not play a large role in its regulation of expression in neural crest tumours.
Positive_regulation (methylation) of CTNNG in neural crest associated with cancer
5) Confidence 0.43 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.83 Pain Relevance 0
-catenin in pancreatic adenocarcinomas, with decreased plasma membrane and increased cytoplasmic staining compared to normal pancreatic ducts and acinar cells by immunohistochemistry [46].
Positive_regulation (increased) of catenin in pancreatic ducts associated with adenocarcinoma
6) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.23 Pain Relevance 0

General Comments

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