INT205153

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.57 Pain Relevance 0

extracellular space (SPP1, MMP9) extracellular region (SPP1, MMP9) peptidase activity (MMP9) proteinaceous extracellular matrix (MMP9) cell adhesion (SPP1) extracellular matrix organization (MMP9)

SPP1 (Homo sapiens) MMP9 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 30 49.12 Pain 4 5.00

Disease Link Frequency Relevance Heat Cancer 62 77.84 Metastasis 34 75.60 Prostate Cancer 80 75.00 Injury 28 74.64 Adhesions 14 5.00 Hypercalcemia 10 5.00 Skin Cancer 10 5.00 Apoptosis 8 5.00 Carcinoma 6 5.00 Cytomegalovirus Infection 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, zymography analysis demonstrated that the levels of MMP-9 activity in the conditioned media reflect the CD44 surface expression pattern of the PC3 cell lines; 4) although MMP-9 and MMP-2 are secreted by PC3 cells, only the secretion of MMP-9 is regulated by OPN expression.

Gene_expression (expression) of OPN Regulation (regulated) of Localization (secretion) of MMP-9

1) Confidence 0.14 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1828067 Disease Relevance 0.27 Pain Relevance 0

MMP-9 activity but not the secreted level of MMP-9 is affected by BP treatment or OPN expression.

Gene_expression (expression) of OPN Regulation (affected) of Localization (secreted) of MMP-9

2) Confidence 0.14 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.30 Pain Relevance 0

General Comments

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