INT205213

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.37
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn4) plasma membrane (Cldn4) molecular_function (Cldn4)
Anatomy Link Frequency
epithelium 12
ileum 2
intestinal epithelium 2
Cldn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 309 98.96 Very High Very High Very High
cytokine 28 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 231 99.34 Very High Very High Very High
Cv Unclassified Under Development 265 98.96 Very High Very High Very High
Cv General 4 Under Development 44 69.36 Quite High
Enteropathy 11 59.12 Quite High
Injury 15 57.44 Quite High
Sepsis 31 56.76 Quite High
Necrosis 11 39.52 Quite Low
Disseminated Intravascular Coagulation 22 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 14 5.00 Very Low Very Low Very Low
Multiple Organ Failure 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the several different effects of the increased and broadened expression of claudin-4 on the intestinal epithelium during ischemia-reperfusion injury that can be considered is the role of claudin-4 in the maintenance of barrier function.
Positive_regulation (increased) of Gene_expression (expression) of claudin-4 in intestinal epithelium associated with reperfusion injury and ischemia
1) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.37 Pain Relevance 0.09
The number of positive pixels per cell was increased at 6 hr post-reperfusion and kept at the increased level at 24 hr post-reperfusion, demonstrating that the area with claudin-4 expression in the cell was increased during the recovery of epithelium.
Positive_regulation (increased) of Gene_expression (expression) of claudin-4 in epithelium
2) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
Our study suggests that claudin-4 overexpression plays an important role in cell migration which is essential at the early stages of epithelial recovery.
Positive_regulation (overexpression) of Gene_expression (overexpression) of claudin-4
3) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.13 Pain Relevance 0.03
The villous epithelium would then be reconstructed when these cells with strong claudin-4 expression reach the apical surface, which would result in increased claudin-4 expression in the villous epithelium.
Positive_regulation (increased) of Gene_expression (expression) of claudin-4 in epithelium
4) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.35 Pain Relevance 0.09
Regarding the different patterns of changes of claudin-4 expression in the crypts and in the villi, we conjecture that the cells that survived the ischemia-reperfusion injury in the crypts were converted to overexpression of claudin-4 and migrated upwards to cover the apical surface.
Positive_regulation (overexpression) of Gene_expression (overexpression) of claudin-4 associated with reperfusion injury and ischemia
5) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.45 Pain Relevance 0.11
Overexpression of claudin-4 was observed in rapidly migrating epithelial cells at the early stages of recovery, whereas at 48 hr post-reperfusion, when the structure of the villi and cell migration had returned to normal, overexpression was no longer observed.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of claudin-4 in epithelial cells
6) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.12 Pain Relevance 0.03
The villous epithelium would then be reconstructed when these cells with strong claudin-4 expression reach the apical surface, which would result in increased claudin-4 expression in the villous epithelium.
Positive_regulation (result) of Gene_expression (expression) of claudin-4 in epithelium
7) Confidence 0.47 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.35 Pain Relevance 0.09
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Positive_regulation (demonstrated) of Gene_expression (expression) of claudin-4 in ileum
8) Confidence 0.34 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.68 Pain Relevance 0.15
The increase of the total gray density value of claudin-4 fluorescence per cell indicates that claudin-4 expression level was increased time-dependently during the recovery of epithelium.
Positive_regulation (increased) of Gene_expression (expression) of claudin-4 in epithelium
9) Confidence 0.32 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0 Pain Relevance 0
In the control sample, claudin-4 expression was restricted to the tips of the villi (Fig. 5A, F) and to the extreme basal part of the crypt (Fig. 5K).
Positive_regulation (restricted) of Gene_expression (expression) of claudin-4
10) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.20 Pain Relevance 0.05
To the contrary, after ischemia-reperfusion injury, the localized expression of claudin-2 and claudin-4 observed in the non-treated control was lost and replaced with broader expression from crypts to villi with increased basolateral claudin-4 expression in epithelial cells.
Positive_regulation (increased) of Gene_expression (expression) of claudin-4 in epithelial cells associated with reperfusion injury and ischemia
11) Confidence 0.28 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1828083 Disease Relevance 0.67 Pain Relevance 0.15
Claudin 4 protein expression significantly increased in both 2CLP and sham monolayers compared to DMSO control.
Positive_regulation (increased) of Gene_expression (expression) of Claudin 4 protein
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.06 Pain Relevance 0

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