INT20546

Context Info Confidence 0.65 First Reported 1990 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.14 Pain Relevance 0.50

aging (IL1B) cytoplasm (SGCG) cell-cell signaling (IL1B) cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)

IL1B (Homo sapiens) SGCG (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 6 68.56 Inflammation 2 61.44 Potency 2 57.96

Disease Link Frequency Relevance Heat INFLAMMATION 4 68.00 Arthropathy 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Etodolac unmasked a stimulatory effect of IL-1 on synthesis of type I collagen and fibronectin and levels of type I collagen mRNA, but to a lesser extent than indomethacin.

IL-1 Regulation (effect) of Gene_expression (synthesis) of type

1) Confidence 0.65 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.07 Pain Relevance 0.25

Etodolac unmasked a stimulatory effect of IL-1 on synthesis of type I collagen and fibronectin and levels of type I collagen mRNA, but to a lesser extent than indomethacin.

IL-1 Regulation (effect) of Gene_expression (synthesis) of type

2) Confidence 0.48 Published 1990 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 2146129 Disease Relevance 0.07 Pain Relevance 0.25

General Comments

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