INT205651

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FUS) cell death (FUS) nucleolus (FUS)
RNA binding (FUS) nucleus (FUS) intracellular (FUS)
FUS (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 5 81.76 Quite High
abdominal pain 3 78.64 Quite High
Onset of action 4 76.64 Quite High
pruritus 2 52.08 Quite High
tolerance 2 31.80 Quite Low
adenocard 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Lysis Syndrome 144 100.00 Very High Very High Very High
Hypersensitivity 47 98.82 Very High Very High Very High
Recurrence 4 98.50 Very High Very High Very High
Adverse Drug Reaction 8 98.16 Very High Very High Very High
Fever 12 93.68 High High
Neutropenia 6 92.56 High High
Respiratory Distress 3 90.24 High High
Sepsis 3 88.08 High High
Mucositis 3 85.60 High High
Hodgkin's Disease 15 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The review provides a comprehensive and detailed review of pathogenesis, laboratory, and clinical presentation of TLS together with clinical studies already performed both in pediatric and adult patients.



Localization (presentation) of TLS
1) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727789 Disease Relevance 0.61 Pain Relevance 0.03
For these reasons, allopurinol remains an alternative when rasburicase is contraindicated (allergic reactions, glucose – 6 – phosphate deydrogenase deficiency) or when TLS risk is low. 1
Localization (risk) of TLS associated with hypersensitivity and tumor lysis syndrome
2) Confidence 0.17 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 1.22 Pain Relevance 0.12
Often, the need for a re-treatment is rarer in neoplastic relapse, because this condition is more resistant to chemotherapy and so at lower risk of TLS development. 13
Localization (risk) of TLS associated with tumor lysis syndrome and recurrence
3) Confidence 0.15 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 2.17 Pain Relevance 0.16
Theoretically, this could also be done by Mus81, but if the enzyme were to cut the stalled fork with the same polarity as the first stalled fork, the ICL would not be released to allow TLS.
Neg (not) Localization (released) of TLS
4) Confidence 0.03 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

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