INT206061

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1, STAT3) plasma membrane (RAC1, STAT3) nucleoplasm (STAT3)
DNA binding (STAT3) enzyme binding (RAC1) GTPase activity (RAC1)
RAC1 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 63.84 Quite High
Inflammation 108 50.00 Quite Low
metalloproteinase 4 20.32 Low Low
Arthritis 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 4 87.80 High High
Malignant Neoplastic Disease 4 72.60 Quite High
Leukemia 4 69.16 Quite High
Apoptosis 16 65.96 Quite High
Cancer 36 60.28 Quite High
INFLAMMATION 136 50.00 Quite Low
Aging 42 50.00 Quite Low
Atherosclerosis 88 5.00 Very Low Very Low Very Low
Osteoporosis 70 5.00 Very Low Very Low Very Low
Diabetes Mellitus 66 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In one study [71], constitutively active Rac1 (Rac V12) is shown to stimulate the activation of STAT3.
Rac1 Positive_regulation (stimulate) of Positive_regulation (activation) of STAT3
1) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.07 Pain Relevance 0.03
Persistently active Rho family and Rac1 results in the activation of JAKs and subsequent tyrosine phosphorylation and activation of STAT3 [74].
Rac1 Positive_regulation (results) of Positive_regulation (activation) of STAT3
2) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.35 Pain Relevance 0

General Comments

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