INT20633

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 15.94
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
liver 4
lymphocyte 4
pericardial fluid 4
blood 2
muscle 2
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 77 97.80 Very High Very High Very High
Pain 4 95.12 Very High Very High Very High
imagery 5 95.04 Very High Very High Very High
tetrodotoxin 1 84.20 Quite High
alcohol 6 84.00 Quite High
cytokine 7 83.00 Quite High
corticosteroid 12 82.00 Quite High
Migraine 3 75.00 Quite High
Bile 5 73.76 Quite High
abdominal pain 6 62.24 Quite High
Disease Link Frequency Relevance Heat
Chronic Hepatitis 31 100.00 Very High Very High Very High
Metastasis 26 99.96 Very High Very High Very High
Lymphopenia 6 99.92 Very High Very High Very High
Cirrhosis 59 99.76 Very High Very High Very High
Lymphadenopathy 5 99.52 Very High Very High Very High
Acute Liver Failure 31 99.46 Very High Very High Very High
Hemorrhage 38 99.32 Very High Very High Very High
Hypoxia 15 99.20 Very High Very High Very High
Renal Disease 11 99.16 Very High Very High Very High
Hepatitis 42 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of alpha-fetoprotein, human chorionic gonadotropin-beta, and lactate dehydrogenase (LDH) were not elevated.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of lactate dehydrogenase
1) Confidence 0.49 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20104012 Disease Relevance 0.86 Pain Relevance 0.10
The serum levels of alpha-fetoprotein, human chorionic gonadotropin-beta, and lactate dehydrogenase (LDH) were not elevated.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of LDH
2) Confidence 0.49 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20104012 Disease Relevance 0.86 Pain Relevance 0.10
The expression of MSIs of CK, GP, PGAM, and LDH was always significantly increased in innervated as compared to noninnervated fibers.
Positive_regulation (increased) of Gene_expression (expression) of LDH
3) Confidence 0.47 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.43 Pain Relevance 0.08
However, pericardial fluid LDH levels were higher than blood LDH levels in this group and were also higher than pericardial fluid LDH levels of other groups.



Positive_regulation (higher) of Gene_expression (levels) of LDH in pericardial fluid
4) Confidence 0.38 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2688157 Disease Relevance 1.29 Pain Relevance 0.12
Some indicators of muscle damage include increased levels of creatine kinase (CK), lactate dehydrogenase (LDH) and muscular soreness [7].
Positive_regulation (increased) of Gene_expression (levels) of LDH in muscle
5) Confidence 0.34 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.17 Pain Relevance 0
However, pericardial fluid LDH levels were higher than blood LDH levels in this group and were also higher than pericardial fluid LDH levels of other groups.



Positive_regulation (higher) of Gene_expression (levels) of LDH in pericardial fluid
6) Confidence 0.33 Published 2006 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2688157 Disease Relevance 1.30 Pain Relevance 0.12
A similar effect can be seen in p38-MAPK, an increased expression of total p38-MAPK in CH, LDH, and CIRR and decreased levels in AH.
Positive_regulation (increased) of Gene_expression (expression) of LDH associated with chronic hepatitis, cirrhosis and hepatitis
7) Confidence 0.29 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.09 Pain Relevance 0.04
The results from multivariate analysis showed that patients who had a PS >= 2 (using the World Health Organization scale), a high overall comorbidity score (on the Adult Comorbidity Evaluation 27), liver metastasis, elevated serum LDH levels, lymphopenia (defined as an absolute lymphocyte count >=0.7 × 109/L), and low serum albumin levels had a worse prognosis.
Positive_regulation (elevated) of Gene_expression (levels) of LDH in lymphocyte associated with lymphopenia and metastasis
8) Confidence 0.24 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.34 Pain Relevance 0
0.02), higher median peak LDH level during hospitalization (1982.5 U/L vs 1230.0 U/L, p?
Positive_regulation (median) of Gene_expression (level) of LDH
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.78 Pain Relevance 0.04
AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; CK, creatine kinase.



Positive_regulation (aspartate aminotransferase) of Gene_expression (aspartate aminotransferase) of lactate dehydrogenase
10) Confidence 0.18 Published 2004 Journal Crit Care Section Body Doc Link PMC420069 Disease Relevance 1.05 Pain Relevance 0
AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; CK, creatine kinase.



Positive_regulation (aspartate aminotransferase) of Gene_expression (aspartate aminotransferase) of LDH
11) Confidence 0.18 Published 2004 Journal Crit Care Section Body Doc Link PMC420069 Disease Relevance 1.05 Pain Relevance 0
Atypical lymphocytes are observed in 25% of the patients.Erythrocyte sedimentation rate and C-reactive protein levels may be elevated.[1]An elevated lactate dehydrogenase level suggests hepatic involvement.[1]

IMAGING STUDIES

Positive_regulation (elevated) of Gene_expression (level) of lactate dehydrogenase in lymphocytes
12) Confidence 0.15 Published 2010 Journal Journal of Oral and Maxillofacial Pathology : JOMFP Section Body Doc Link PMC2996003 Disease Relevance 1.65 Pain Relevance 0.21
To identify possible mechanisms of hepatotoxicity, we investigated liver function in vitro at > 170-fold of therapeutic C(max) levels, including cytotoxicity (lactate dehydrogenase, MTT, and ATP), transaminase activities (alanine aminotransferase and aspartate aminotransferase), albumin synthesis, urea and testosterone metabolism to assay for cytochrome P450 monooxygenase activity.
Positive_regulation (assay) of Gene_expression (activities) of lactate dehydrogenase in liver associated with hepatotoxicity
13) Confidence 0.10 Published 2009 Journal Toxicol. Sci. Section Abstract Doc Link 19770483 Disease Relevance 0.70 Pain Relevance 0.18
The bleeding alone group was characterized by elevated LDH activity levels in the context of a higher RBC (but not WBC) count, and normal IL-6 and MMP-8 levels.
Positive_regulation (elevated) of Gene_expression (levels) of LDH associated with hemorrhage
14) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 1.20 Pain Relevance 0.26
Other laboratory values were also normal with sodium, 133 meq/L; potassium, 3.5 meq/L; chloride, 90 meq/L; bicarbonate, 30 meq/L; blood urea nitrogen, 17 mg/dL; creatinine, 0.7 mg/dL; alkaline phosphatase, 86 U/L; bilirubin, 0.6 mg/dL; aspartate aminotransferase, 39 U/L; alanine aminotransferase, 21 U/L; lactate dehydrogenase of 190 U/L; amylase, 58 U/L; and lipase, 15 U/L.
Positive_regulation (alanine aminotransferase) of Gene_expression (alanine aminotransferase) of lactate dehydrogenase in blood
15) Confidence 0.03 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824723 Disease Relevance 0.55 Pain Relevance 0.17
Based on the evidence that over-activation of macrophages, followed by disturbance of the hepatic microcirculation, plays a key role in ALF, we hypothesized that the production of serum lactate dehydrogenase (LDH) might increase in the liver under hypoxic conditions and could be an indicator to discriminate between conservative survivors and fatal patients at an early stage.


Spec (might) Positive_regulation (increase) of Gene_expression (production) of lactate dehydrogenase in liver associated with hypoxia and acute liver failure
16) Confidence 0.02 Published 2008 Journal Comp Hepatol Section Abstract Doc Link PMC2527551 Disease Relevance 0.61 Pain Relevance 0

General Comments

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