INT206482

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.60
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
neuronal 1
precursor cells 1
brains 1
hippocampus 1
Nes (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 37 97.94 Very High Very High Very High
cerebral cortex 3 82.56 Quite High
antagonist 15 68.88 Quite High
Morphine 6 63.84 Quite High
cocaine 6 63.04 Quite High
narcan 1 55.52 Quite High
midbrain 16 53.68 Quite High
withdrawal 8 53.44 Quite High
Dopamine 117 50.00 Quite Low
addiction 36 50.00 Quite Low
Disease Link Frequency Relevance Heat
Death 10 96.84 Very High Very High Very High
Neurodegenerative Disease 98 92.20 High High
Sprains And Strains 11 89.68 High High
Infection 59 87.84 High High
Macrocephaly 2 79.04 Quite High
Hypertrophy 3 76.72 Quite High
Body Weight 2 76.64 Quite High
Glioblastoma 2 75.52 Quite High
Targeted Disruption 24 75.48 Quite High
Congenital Anomalies 2 74.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hippocampus of wild type mice we found an upregulation of CB1 receptor mRNA in the ENR and RUN mice along with an increase in Nestin mRNA only in the RUN paradigm.
Positive_regulation (increase) of Nestin mRNA in hippocampus associated with hippocampus
1) Confidence 0.46 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.47 Pain Relevance 0.13
Irrespective of the passage number the precursor cells showed immunoreactions for nestin and BrdU.
Positive_regulation (immunoreactions) of nestin in precursor cells
2) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.17 Pain Relevance 0
The nestin promoter/enhancer is associated with widespread central deletion of the Creb gene, as nestin expresses from embryonic stage in all brain regions before separation of neuronal and glial lineages [68], with CREB loss observed in neurons and glial cells.
Positive_regulation (enhancer) of nestin in neuronal
3) Confidence 0.22 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.22 Pain Relevance 0.20
These figures clearly indicate that the surface expression of costimulatory and MHC class I molecules underwent an increase in the Nestin positive cells in the SVZ of JEV infected animals.


Positive_regulation (increase) of Nestin
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.21 Pain Relevance 0
For example, the use of a Nestin promoter to induce Pten deletion in neural stem cells and glial progenitors resulted in neonatal death, as mice showed enlarged and histoarchitecturally abnormal brains [10].
Positive_regulation (induce) of Nestin promoter in brains associated with death
5) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.52 Pain Relevance 0.11

General Comments

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