INT206742

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PRDX2) oxidoreductase activity (PRDX2) cytoplasm (PRDX2)
PRDX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 20.24 Low Low
cINOD 39 5.00 Very Low Very Low Very Low
antagonist 21 5.00 Very Low Very Low Very Low
aspirin 21 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
diclofenac 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 33 99.52 Very High Very High Very High
Repression 10 99.48 Very High Very High Very High
Cancer 440 99.16 Very High Very High Very High
Apoptosis 97 98.32 Very High Very High Very High
Carcinoma 12 97.68 Very High Very High Very High
Chronic Lymphoid Leukemia 2 96.24 Very High Very High Very High
Pancreatic Cancer 54 95.92 Very High Very High Very High
Lymphatic System Cancer 15 91.48 High High
Adenocarcinoma 27 84.60 Quite High
Nasopharynx Cancer 5 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of thioredoxin peroxidase 2 and protein disulfide isomerase also correlated to decreased survival times.
Negative_regulation (regulation) of thioredoxin peroxidase 2
1) Confidence 0.04 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.23 Pain Relevance 0
In a recently published study by our research group, we demonstrated that HDAC Class I and II inhibitors such as TSA can induce death of tumor cell lines via apoptosis [63].
Negative_regulation (inhibitors) of TSA associated with cancer, apoptosis and death
2) Confidence 0.04 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.27 Pain Relevance 0
In recent in vitro studies, HDACi inhibitors such as TSA and SAHA have been shown to induce pancreatic cell death by apoptosis [60].
Negative_regulation (inhibitors) of TSA associated with apoptosis and death
3) Confidence 0.04 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.02 Pain Relevance 0
This is in agreement with data shown by Ohira et al who have shown induction of the Wnt signaling pathway target gene, E-cadherin, by HDAC inhibition with TSA or GSK3?
Negative_regulation (inhibition) of TSA
4) Confidence 0.02 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.54 Pain Relevance 0
HDAC inhibitors such as butyrate and TSA, block this repression resulting in a reduction of the threshold necessary to activate Tcf transcription.
Negative_regulation (inhibitors) of TSA associated with repression
5) Confidence 0.02 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.43 Pain Relevance 0
Sodium butyrate and TSA are inhibitors of HDAC activity independent of their effects on ?
Negative_regulation (inhibitors) of TSA
6) Confidence 0.02 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.54 Pain Relevance 0

General Comments

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