INT206760

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 15.76
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 2
brain 1
T cells 1
Nqo1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 145 100.00 Very High Very High Very High
Spinal cord 148 96.52 Very High Very High Very High
Central nervous system 264 96.44 Very High Very High Very High
Inflammation 106 95.84 Very High Very High Very High
Neuritis 202 90.60 High High
imagery 13 84.92 Quite High
potassium channel 10 84.32 Quite High
Demyelination 18 79.12 Quite High
cytokine 24 68.64 Quite High
midbrain 4 63.12 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 1264 100.00 Very High Very High Very High
Disease 362 100.00 Very High Very High Very High
Demyelinating Disease 246 100.00 Very High Very High Very High
Multiple Sclerosis 124 100.00 Very High Very High Very High
Autoimmune Disease 98 97.20 Very High Very High Very High
Injury 2 96.48 Very High Very High Very High
INFLAMMATION 102 95.84 Very High Very High Very High
Trepenoma Infection 4 94.52 High High
Transverse Myelitis 166 93.92 High High
Syndrome 58 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Negative controls in each experiment included sera from two healthy subjects and positive controls included rabbit anti-human AQP4 antibody (Santa Cruz, CA) as mentioned above and two NMO patients seropositive for NMO-IgG as confirmed by the Clinical Neuroimmunology Laboratory of Mayo Clinic, Rochester, Minnesota.
Localization (seropositive) of NMO-IgG associated with neuromyelitis optica
1) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0.35 Pain Relevance 0
In addition, among their 21 NMO patients seropositive for AQP4 autoantibodies by cell-based IIFA, patients seropositive for NMO-IgG by tissue-based IIFA (15 patients) had a higher frequency of longitudinally extensive spinal cord lesions on MRI than patients seronegative for NMO-IgG by tissue-based IIFA (6 patients), 100% versus 50% (p = 0.015) [34]; this was not observed in our patients.
Localization (seropositive) of NMO-IgG in spinal cord associated with neuromyelitis optica and spinal cord
2) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 1.66 Pain Relevance 0.18
Negative controls in each experiment included sera from two healthy subjects and positive controls included rabbit anti-human AQP4 antibody (Santa Cruz, CA) as mentioned above and two NMO patients seropositive for NMO-IgG as confirmed by the Clinical Neuroimmunology Laboratory of Mayo Clinic, Rochester, Minnesota.
Localization (seropositive) of NMO associated with neuromyelitis optica
3) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 0.35 Pain Relevance 0
In addition, among their 21 NMO patients seropositive for AQP4 autoantibodies by cell-based IIFA, patients seropositive for NMO-IgG by tissue-based IIFA (15 patients) had a higher frequency of longitudinally extensive spinal cord lesions on MRI than patients seronegative for NMO-IgG by tissue-based IIFA (6 patients), 100% versus 50% (p = 0.015) [34]; this was not observed in our patients.
Localization (seropositive) of NMO in spinal cord associated with neuromyelitis optica and spinal cord
4) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance 1.70 Pain Relevance 0.18
It is not known how often patients with NMO or other demyelinating diseases make antibodies to AQP4, so it is unclear whether testing for these antibodies would help in the diagnosis of NMO.
Localization (diseases) of NMO associated with neuromyelitis optica and demyelinating disease
5) Confidence 0.05 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance 1.65 Pain Relevance 0.29
Accumulating evidences reveal that NMO-IgG localizes to blood-brain barrier (BBB) [54]: an indirect immunofluorescence study with dual immunolabeling of mouse brain sections with NMO patient’ sera and antibodies specific for the endothelial marker factor VIII, the reactive-astrocyte marker glial fibrillary acidic protein (GFAP) or the extracellular matrix protein laminin, has suggested that the main target antigen is in astrocytes located adjacent to the BBB [54].
Localization (localizes) of NMO in brain associated with neuromyelitis optica
6) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.60 Pain Relevance 0.20
Lennon and colleagues [54] described an IgG, the presence of which was 73% sensitive and 91% specific for clinically defined NMO.
Localization (presence) of NMO associated with neuromyelitis optica
7) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 2.43 Pain Relevance 0.40
There are at least two antigens for which specific T cells might be relevant for NMO, as both MOG and AQP4 antibodies have been detected in CSF and sera of NMO patients.
Localization (relevant) of NMO in T cells associated with neuromyelitis optica
8) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.68 Pain Relevance 0.24
In many of the cases of parainfectious NMO the presence of AQP4-specific antibodies is not reported and some CSF profiles are not consistent with NMO.
Localization (presence) of NMO associated with neuromyelitis optica
9) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.47 Pain Relevance 0.12
Pathology of human NMO – then and now
Localization (Pathology) of NMO associated with neuromyelitis optica
10) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.68 Pain Relevance 0.65
There is a current debate as to whether NMO and Asian MS are the same disease.
Localization (disease) of NMO associated with neuromyelitis optica, multiple sclerosis and disease
11) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.18 Pain Relevance 0.13

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