INT206764

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| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Pain Relations:'''
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Term
(frequency)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Demyelination]] (16)
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Brainstem]] (2)
+
|-
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Demyelination]]
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Corticosteroids]] (4)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 16
{{#icon: cold.png|Quite Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.46
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Functional magnetic resonance imaging]] (10)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
{{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
+
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Gray cellular mantle]] (6)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[medulla]]
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Spinal cord]] (52)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 95.96
{{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[corticosteroid]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 4
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 42.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Quite Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[imagery]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 10
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 14.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[cerebral cortex]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Spinal cord]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 52
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Central nervous system]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[midbrain]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[carpal tunnel syndrome]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[intrathecal]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|-
 
|-
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
(frequency)
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Autonomic Nervous System Disease]] (2)
 
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Respiratory Failure]] (5)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Channelopathies]] (2)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Syndrome]] (24)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyalinosis]] (3)
 
{{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Necrosis]] (6)
 
{{#icon: chilli.png|Quite High}}
 
|}
 
  
 +
|}|
 +
|
 +
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
|}
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Term
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
 +
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Autonomic Nervous System Disease]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Respiratory Failure]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 94.08
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Channelopathies]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 91.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Syndrome]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 24
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 87.52
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyalinosis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 82.88
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Necrosis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 6
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 82.48
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyperplasia]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 82.12
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Congenital Anomalies]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 79.36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Relapsing-remitting Multiple Sclerosis]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 69.72
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Increased Venous Pressure Under Development]]
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 61.36
 +
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 +
|-
 +
|}
 
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Revision as of 12:16, 12 September 2012

Context Info
Confidence 0.1904229200
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 8
Total Number 9

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AQP4, Nqo1) cytosol (Nqo1) transport (AQP4)
oxidoreductase activity (Nqo1) plasma membrane (AQP4) transmembrane transport (AQP4)
AQP4 (Homo sapiens)
Nqo1 (Mus musculus)
Pain Term Frequency Confidence Heat
Demyelination 16 99.46 Very High Very High Very High
medulla 2 95.96 Very High Very High Very High
corticosteroid 4 42.48 Quite Low
imagery 10 14.72 Low Low
cerebral cortex 6 5 Very Low Very Low Very Low
Spinal cord 52 5 Very Low Very Low Very Low
Central nervous system 36 5 Very Low Very Low Very Low
midbrain 6 5 Very Low Very Low Very Low
carpal tunnel syndrome 2 5 Very Low Very Low Very Low
intrathecal 36 5 Very Low Very Low Very Low
|
Disease Term Frequency Confidence Heat
Autonomic Nervous System Disease 2 97.36 Very High Very High Very High
Respiratory Failure 5 94.08 High High
Channelopathies 2 91.72 High High
Syndrome 24 87.52 High High
Hyalinosis 3 82.88 Quite High
Necrosis 6 82.48 Quite High
Hyperplasia 3 82.12 Quite High
Congenital Anomalies 8 79.36 Quite High
Relapsing-remitting Multiple Sclerosis 2 69.72 Quite High
Increased Venous Pressure Under Development 2 61.36 Quite High

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
AQP4 Binding (binds) of NMO-IgG
1) Confidence 0.0466765778031529 Published 2010 Journal N/A Section N/A Doc Link PMC2941752
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
aquaporin-4 Binding (binds) of NMO-IgG
2) Confidence 0.0466765778031529 Published 2010 Journal N/A Section N/A Doc Link PMC2941752
Thus we hypothesized that AQP4 antibodies in fact characterize NMO patients.


AQP4 Binding (characterize) of NMO
3) Confidence 0.0285731317677099 Published 2007 Journal N/A Section N/A Doc Link PMC1852124
It is therefore still unclear whether antibodies to AQP4 are specific for NMO and whether testing for these antibodies may be useful for its diagnosis and its distinction from diseases with similar clinical and neuroradiological patterns, such as MS and other autoimmune diseases with involvement of the CNS.
AQP4 Binding (specific) of NMO
4) Confidence 0.0274655216036807 Published 2007 Journal N/A Section N/A Doc Link PMC1852124
The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.
AQP4 Binding (interaction) of NMO
5) Confidence 0.0229482138959204 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
Moreover, two pathologic patterns in NMO, both of which were associated with loss of AQP4 immunoreactivity were described [39].
AQP4 Binding (associated) of NMO
6) Confidence 0.0177522037091431 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
In summary, the intriguing report by Roemer and colleagues [80], describing loss of AQP4 in the absence of demyelination or necrosis suggests that binding of antibody to AQP4 may be the initial pathogenic event in NMO lesions.
AQP4 Binding (binding) of NMO
7) Confidence 0.0177522037091431 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
aquaporin-4 Binding (associated) of NMO
8) Confidence 0.00502201274017981 Published 2010 Journal N/A Section N/A Doc Link PMC2945323
In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
AQP4 Binding (associated) of NMO
9) Confidence 0.00502201274017981 Published 2010 Journal N/A Section N/A Doc Link PMC2945323

General Comments

This test has worked.

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