INT206764

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| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
| style="color: black; background:#AAFCFB; white-space:wrap;"| '''Disease Relations:'''
 
(frequency)
 
(frequency)
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[autonomic nervous system disease]] (2)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Autonomic Nervous System Disease]] (2)
 
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
{{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[respiratory failure]] (5)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Respiratory Failure]] (5)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[channelopathies]] (2)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Channelopathies]] (2)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[syndrome]] (24)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Syndrome]] (24)
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
{{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[hyalinosis]] (3)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyalinosis]] (3)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[necrosis]] (6)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Necrosis]] (6)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[hyperplasia]] (3)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hyperplasia]] (3)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[congenital anomalies]] (8)
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Congenital Anomalies]] (8)
 
{{#icon: chilli.png|Quite High}}
 
{{#icon: chilli.png|Quite High}}
 
|}
 
|}
|
+
{| cellpadding=3 cellspacing=0
mutations
+
|-
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Protein
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Mutation
 +
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 +
|-
 +
 
 +
|}
 
|-
 
|-
 
|}
 
|}

Revision as of 11:15, 12 September 2012

Context Info
Confidence 0.1904229200
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in NULL
Documents 8
Total Number 9

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AQP4, Nqo1) cytosol (Nqo1) transport (AQP4)
oxidoreductase activity (Nqo1) plasma membrane (AQP4) transmembrane transport (AQP4)
AQP4 (Homo sapiens)
Nqo1 (Mus musculus)
Pain Relations:

(frequency)

Demyelination (16)

Very High Very High Very High

Brainstem (2)

Very High Very High Very High

Corticosteroids (4)

Quite Low

Functional magnetic resonance imaging (10)

Low Low

Gray cellular mantle (6)

Very Low Very Low Very Low

Spinal cord (52)

Very Low Very Low Very Low

Central nervous system (36)

Very Low Very Low Very Low

midbrain (6)

Very Low Very Low Very Low

Disease Relations:

(frequency)

Autonomic Nervous System Disease (2)

Very High Very High Very High

Respiratory Failure (5)

High High

Channelopathies (2)

High High

Syndrome (24)

High High

Hyalinosis (3)

Quite High

Necrosis (6)

Quite High

Hyperplasia (3)

Quite High

Congenital Anomalies (8)

Quite High

Protein Mutation Frequency

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
AQP4 Binding (binds) of NMO-IgG
1) Confidence 0.0466765778031529 Published 2010 Journal N/A Section N/A Doc Link PMC2941752
Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].
aquaporin-4 Binding (binds) of NMO-IgG
2) Confidence 0.0466765778031529 Published 2010 Journal N/A Section N/A Doc Link PMC2941752
Thus we hypothesized that AQP4 antibodies in fact characterize NMO patients.


AQP4 Binding (characterize) of NMO
3) Confidence 0.0285731317677099 Published 2007 Journal N/A Section N/A Doc Link PMC1852124
It is therefore still unclear whether antibodies to AQP4 are specific for NMO and whether testing for these antibodies may be useful for its diagnosis and its distinction from diseases with similar clinical and neuroradiological patterns, such as MS and other autoimmune diseases with involvement of the CNS.
AQP4 Binding (specific) of NMO
4) Confidence 0.0274655216036807 Published 2007 Journal N/A Section N/A Doc Link PMC1852124
The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.
AQP4 Binding (interaction) of NMO
5) Confidence 0.0229482138959204 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
Moreover, two pathologic patterns in NMO, both of which were associated with loss of AQP4 immunoreactivity were described [39].
AQP4 Binding (associated) of NMO
6) Confidence 0.0177522037091431 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
In summary, the intriguing report by Roemer and colleagues [80], describing loss of AQP4 in the absence of demyelination or necrosis suggests that binding of antibody to AQP4 may be the initial pathogenic event in NMO lesions.
AQP4 Binding (binding) of NMO
7) Confidence 0.0177522037091431 Published 2010 Journal N/A Section N/A Doc Link PMC2923365
In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
aquaporin-4 Binding (associated) of NMO
8) Confidence 0.00502201274017981 Published 2010 Journal N/A Section N/A Doc Link PMC2945323
In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
AQP4 Binding (associated) of NMO
9) Confidence 0.00502201274017981 Published 2010 Journal N/A Section N/A Doc Link PMC2945323

General Comments

This test has worked.

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