INT206764

Context Info Confidence 0.05 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 9 Disease Relevance 13.44812 Pain Relevance 5.01142

cytoplasm (AQP4, Nqo1) cytosol (Nqo1) transport (AQP4) oxidoreductase activity (Nqo1) plasma membrane (AQP4) transmembrane transport (AQP4)

AQP4 (Homo sapiens) Nqo1 (Mus musculus)

Pain Term Frequency Confidence Heat Multiple sclerosis 100 100 Demyelination 16 99.46 medulla 2 95.96 Spinal cord 52 92.32 Central nervous system 36 90.92 addiction 9 84.08 Neuritis 97 81.76 imagery 10 74.52 Inflammation 59 60.48 intrathecal 36 53.36

Disease Term Frequency Confidence Heat Demyelinating Disease 220 100 Neuromyelitis Optica 481 100 Necrosis 6 99.7 Autonomic Nervous System Disease 2 97.36 Disease 261 96.04 Respiratory Failure 5 94.08 Autoimmune Disease 19 92.68 Channelopathies 2 91.72 Central Nervous System Disease 22 90.92 Syndrome 24 87.52

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Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].

AQP4 Binding (binds) of NMO-IgG

1) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance N/A Pain Relevance N/A

Lennon and colleagues discovered a biomarker for NMO; NMO-IgG is an autoantibody initially detected in the serum of 73% of NMO but less than 5% of CMS patients [10], which binds to aquaporin-4 (AQP4) [11], the most abundant water channel in the CNS [12-14].

aquaporin-4 Binding (binds) of NMO-IgG

2) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2941752 Disease Relevance N/A Pain Relevance N/A

Thus we hypothesized that AQP4 antibodies in fact characterize NMO patients.

AQP4 Binding (characterize) of NMO

3) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1852124 Disease Relevance N/A Pain Relevance N/A

It is therefore still unclear whether antibodies to AQP4 are specific for NMO and whether testing for these antibodies may be useful for its diagnosis and its distinction from diseases with similar clinical and neuroradiological patterns, such as MS and other autoimmune diseases with involvement of the CNS.

AQP4 Binding (specific) of NMO

4) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1852124 Disease Relevance N/A Pain Relevance N/A

The limited access of circulating IgG to the extracapillary space in the CNS would only permit interaction of NMO-IgG with AQP4 at the glia limitans of BBB: in consequence of these findings, many authors suggest the perivascular space as the primary target site of the pathogenic process.

AQP4 Binding (interaction) of NMO

5) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance N/A Pain Relevance N/A

Moreover, two pathologic patterns in NMO, both of which were associated with loss of AQP4 immunoreactivity were described [39].

AQP4 Binding (associated) of NMO

6) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance N/A Pain Relevance N/A

In summary, the intriguing report by Roemer and colleagues [80], describing loss of AQP4 in the absence of demyelination or necrosis suggests that binding of antibody to AQP4 may be the initial pathogenic event in NMO lesions.

AQP4 Binding (binding) of NMO

7) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance N/A Pain Relevance N/A

In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).

aquaporin-4 Binding (associated) of NMO

8) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2945323 Disease Relevance N/A Pain Relevance N/A

In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).

AQP4 Binding (associated) of NMO

9) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2945323 Disease Relevance N/A Pain Relevance N/A

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