INT206858

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.40
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
Anatomy Link Frequency
uterus 1
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 85 99.24 Very High Very High Very High
Arthritis 3 96.28 Very High Very High Very High
Central nervous system 1 81.92 Quite High
rheumatoid arthritis 9 79.32 Quite High
Osteoarthritis 3 66.16 Quite High
chemokine 6 62.92 Quite High
cytokine 7 56.20 Quite High
agonist 7 50.00 Quite Low
cINOD 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 99.24 Very High Very High Very High
Cancer 69 97.44 Very High Very High Very High
Arthritis 6 96.28 Very High Very High Very High
Uterine Fibroids 72 92.44 High High
Breast Cancer 56 87.84 High High
Chromosome Aberrations 1 85.36 High High
Disease 11 85.00 Quite High
Rheumatoid Arthritis 32 79.32 Quite High
Apoptosis 24 76.20 Quite High
Adhesions 6 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is positive regulation upon AnxA1 (or peptide Ac2-26) addition, conveyed by ALX activation, and there is also negative regulation in tonic absence of this protein, as observed in AnxA1null mice.


Regulation (regulation) of AnxA1
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.05 Pain Relevance 0
Another striking finding was the up-regulation of JAG1 consequent to AnxA1.
Regulation (regulation) of AnxA1
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.19 Pain Relevance 0.09
Our new data indicate that, in inflammatory settings, expression of JAM-3 may be modulated upon AnxA1 administration (pharmacological studies) or AnxA1 deficiency (patho-physiological investigations).
Spec (may) Regulation (modulated) of AnxA1 associated with inflammation
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.92 Pain Relevance 0.33
It is worthwhile to note that directions of expression changes of ANXA1, NR4A1 and PLP1 were opposite from that of the estrogen treated rat uterus.
Regulation (changes) of ANXA1 in uterus
4) Confidence 0.13 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.83 Pain Relevance 0.04
Notably WalBC cells showed up regulated expression of DSP, s100A4, ANXA1, NDRG-1, TK1 and down regulation of genes such as tissue inhibitor of TIMP-3 and TAGLN.
Regulation (regulation) of ANXA1
5) Confidence 0.05 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.41 Pain Relevance 0

General Comments

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