INT207075

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.95
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bladder 1
Upk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 162 99.78 Very High Very High Very High
interstitial cystitis 3 80.68 Quite High
Inflammatory response 21 65.84 Quite High
addiction 1 50.00 Quite Low
substance P 42 17.36 Low Low
Inflammatory stimuli 15 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 198 99.78 Very High Very High Very High
Disease 16 97.88 Very High Very High Very High
Urinary Tract Disease 3 97.08 Very High Very High Very High
Hematological Disease 6 89.84 High High
Bladder Cancer 97 87.76 High High
Adhesions 6 86.96 High High
Targeted Disruption 15 86.32 High High
Cancer 77 85.48 High High
Death 6 83.84 Quite High
Apoptosis 9 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to genes involved in inflammation, we found upregulation of members of the tetraspanin family (cd63, and adam3) and upk2 that dimerises with the tetraspanin uroplakin 1a.
Positive_regulation (upregulation) of upk2 associated with inflammation
1) Confidence 0.60 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.96 Pain Relevance 0.40
This type of analysis also revealed PAR-1 dependent genes (upk2, jundD, ptprc, and nfkbp1a) encoding proteins associated with renal and urological diseases.
Positive_regulation (dependent) of upk2 associated with urinary tract disease
2) Confidence 0.40 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 1.00 Pain Relevance 0.14
Seventeen days after castration in UPII-SV40T, TSP1 bladder protein expression was increased 3.8-fold (p = 0.0154) compared to intact animals (Fig. 7B, C).
Positive_regulation (increased) of UPII-SV40T in bladder
3) Confidence 0.29 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.50 Pain Relevance 0
With the exception of pla2G1b, these results indicate that treatment of wild type mice with PAR1- and PAR2-AP induced up-regulation of the following PAR1-dependent genes: actb, akt2, arf6, ccl7, cd63, dusp1, fkbp1a, nfkbia, phlda1, plaur, s100a10, tnfaip3, ube2h, and upk2.


Positive_regulation (induced) of upk2
4) Confidence 0.18 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

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