INT207098

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.49
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tnfaip3) nucleus (Tnfaip3) DNA binding (Tnfaip3)
ligase activity (Tnfaip3) cytoplasm (Tnfaip3)
Anatomy Link Frequency
A20 4
Tnfaip3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 118 86.00 High High
cytokine 58 84.28 Quite High
rheumatoid arthritis 20 16.96 Low Low
substance P 14 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 8 99.60 Very High Very High Very High
Systemic Lupus Erythematosus 244 99.44 Very High Very High Very High
Cancer 25 99.24 Very High Very High Very High
Autoimmune Disease 92 97.12 Very High Very High Very High
INFLAMMATION 130 86.00 High High
Disease 69 78.76 Quite High
Urinary Tract Disease 1 66.20 Quite High
Hematological Disease 2 51.52 Quite High
Death 2 45.52 Quite Low
Apoptosis 22 44.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced protein 3 (TNFAIP3, or A20) and IRF4.
Positive_regulation (induced) of TNFAIP3 in A20
1) Confidence 0.39 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.26 Pain Relevance 0.14
Currently, active research on this topic is concerned with negatively regulating molecules that activate TLR-dependent signaling, but what about activating some of the natural inhibitory proteins, such as Triad3A, MyD88s, SHP-1, IRAK-M, IRAK1c, IRF4, and A20?
Positive_regulation (activate) of A20 in A20
2) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.70 Pain Relevance 0.08
-induced protein 3 (TNFAIP3, or A20) and IRF4.
Positive_regulation (induced) of A20 in A20
3) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.26 Pain Relevance 0.14
Similarly, promoting the production or activity of the other endogenous TLR signaling inhibitors, Triad3A, MyD88s, SHP-1, IRAK1c, IRF4, or A20, could provide additional options for effective treatment for systemic autoimmunity.
Positive_regulation (promoting) of A20 in A20 associated with autoimmune disease
4) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.79 Pain Relevance 0.14
With the exception of pla2G1b, these results indicate that treatment of wild type mice with PAR1- and PAR2-AP induced up-regulation of the following PAR1-dependent genes: actb, akt2, arf6, ccl7, cd63, dusp1, fkbp1a, nfkbia, phlda1, plaur, s100a10, tnfaip3, ube2h, and upk2.


Positive_regulation (induced) of tnfaip3
5) Confidence 0.10 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

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