INT207336

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell differentiation (GLI2) cell proliferation (GLI2) mitochondrion (CYP27A1) small molecule metabolic process (CYP27A1) nucleus (GLI2) intracellular (GLI2)

Anatomy Link Frequency monocytes 3 GLI2 (Homo sapiens) CYP27A1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 13 5.00 cINOD 10 5.00 Inflammation 5 5.00 Pain 3 5.00 Analgesic 1 5.00 withdrawal 1 5.00 diclofenac 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 9 5.00 Myocardial Infarction 8 5.00 INFLAMMATION 7 5.00 Thrombosis 3 5.00 Death 3 5.00 Pain 3 5.00 Atherosclerotic Plaque 3 5.00 Stroke 3 5.00 Cardiovascular Disease 2 5.00 Disorder Of Lipid Metabolism 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exposure to NS398 markedly reduced cholesterol 27-hydroxylase message expression by THP-1 monocytes (50 ?

Gene_expression (monocytes) of THP-1 in monocytes Negative_regulation (reduced) of Gene_expression (expression) of 27-hydroxylase in monocytes

1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0

General Comments

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