INT207345

Context Info Confidence 0.21 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.17

transport (PTGDS, ABCA1) Golgi apparatus (PTGDS, ABCA1) isomerase activity (PTGDS) small molecule metabolic process (ABCA1) intracellular (ABCA1) lipid metabolic process (ABCA1)

Anatomy Link Frequency macrophages 2 PTGDS (Homo sapiens) ABCA1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 13 96.84 cINOD 10 5.00 Inflammation 5 5.00 Pain 3 5.00 Analgesic 1 5.00 withdrawal 1 5.00 diclofenac 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 9 5.00 Myocardial Infarction 8 5.00 INFLAMMATION 7 5.00 Thrombosis 3 5.00 Death 3 5.00 Pain 3 5.00 Atherosclerotic Plaque 3 5.00 Stroke 3 5.00 Cardiovascular Disease 2 5.00 Disorder Of Lipid Metabolism 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reversal of NS398-induced downregulation of 27-hydroxylase and ABCA1 message by PGE2 and PGD2 was also observed in THP-1 macrophages (Figure 6).

PGD2 Negative_regulation (downregulation) of Gene_expression (message) of ABCA1 in macrophages

1) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.17

General Comments

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