INT207360

Context Info Confidence 0.25 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.14

transport (PTGDS, ABCA1) Golgi apparatus (PTGDS, ABCA1) isomerase activity (PTGDS) small molecule metabolic process (ABCA1) intracellular (ABCA1) lipid metabolic process (ABCA1)

PTGDS (Homo sapiens) ABCA1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 13 99.80 cINOD 10 5.00 Inflammation 5 5.00 Pain 3 5.00 Analgesic 1 5.00 withdrawal 1 5.00 diclofenac 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 9 5.00 Myocardial Infarction 8 5.00 INFLAMMATION 7 5.00 Thrombosis 3 5.00 Death 3 5.00 Pain 3 5.00 Atherosclerotic Plaque 3 5.00 Stroke 3 5.00 Cardiovascular Disease 2 5.00 Disorder Of Lipid Metabolism 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

COX-2 inhibitor-mediated downregulation of 27-hydroxylase and ABCA1 mRNA is reversed by prostaglandins PGE1, PGE2, and PGD2

PGD2 Negative_regulation (reversed) of Negative_regulation (downregulation) of ABCA1 mRNA associated with cox-2 inhibitor

1) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14

General Comments

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