INT207379

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.70
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
bone tissue 2
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 99.84 Very High Very High Very High
Arthritis 19 97.04 Very High Very High Very High
rheumatoid arthritis 34 86.16 High High
cytokine 5 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 30 99.84 Very High Very High Very High
INFLAMMATION 27 99.84 Very High Very High Very High
Hypercalcemia 25 98.60 Very High Very High Very High
Arthritis 19 97.04 Very High Very High Very High
Rheumatoid Arthritis 34 86.16 High High
Osteopetrosis 1 72.64 Quite High
Targeted Disruption 2 64.16 Quite High
Arthropathy 2 57.84 Quite High
Disease 5 38.40 Quite Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, inflammation is not affected by the inhibition of RANKL.
Neg (not) Regulation (affected) of Negative_regulation (inhibition) of RANKL associated with inflammation
1) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.19 Pain Relevance 0.50
Role of RANKL inhibition in osteoporosis

When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton.

Regulation (Role) of Negative_regulation (inhibition) of RANKL in bone tissue associated with hypercalcemia and osteoporosis
2) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC1924518 Disease Relevance 0.52 Pain Relevance 0

General Comments

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