INT207532

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.18
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Luc7l3) mRNA processing (Luc7l3) plasma membrane (Luc7l3)
nucleus (Luc7l3) DNA binding (Luc7l3) response to stress (Luc7l3)
Anatomy Link Frequency
retina 2
neurons 2
amacrine cells 1
retinal layers 1
Luc7l3 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 1290 99.74 Very High Very High Very High
Dopamine 750 99.12 Very High Very High Very High
antagonist 281 98.52 Very High Very High Very High
imagery 66 97.58 Very High Very High Very High
Neurotransmitter 230 96.64 Very High Very High Very High
Action potential 134 94.76 High High
GABAergic 130 94.48 High High
agonist 281 80.40 Quite High
GABA receptor 90 75.88 Quite High
dopamine receptor 40 57.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 260 98.08 Very High Very High Very High
Aids-related Complex 80 78.64 Quite High
Body Weight 2 77.68 Quite High
Weight Loss 1 77.28 Quite High
Repression 8 50.00 Quite Low
Neuroblastoma 2 21.44 Low Low
Targeted Disruption 31 5.00 Very Low Very Low Very Low
Contagious Ecthyma 14 5.00 Very Low Very Low Very Low
Dislocations 12 5.00 Very Low Very Low Very Low
Decapitation 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
bp fragments of cDNAs, corresponding to LUC or LacZ, respectively: LUC primers, 5?
Localization (respectively) of LUC
1) Confidence 0.28 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0
To confirm that inner retinal PER2::LUC is rhythmic, populations of retinal slices maintained in constant culture conditions were imaged at 6-h intervals (n = 2 independent runs; Figure 2B).
Localization (retinal) of LUC
2) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.16 Pain Relevance 0.06
Similar inner nuclear layer localization of PER2::LUC expression was observed in retinas from C57BL/6J mice as well (unpublished data).
Localization (localization) of LUC in retinas
3) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.20 Pain Relevance 0.08
Using this protocol, we characterized retinal PER2::LUC expression rhythms, localized their source within the retinal layers, examined the influence of multiple retinal neurotransmitters, as well as sodium-dependent action potentials and cx36-containing gap junctions, and characterized light resetting of retinal oscillations.
Localization (localized) of LUC in retinal layers associated with action potential and neurotransmitter
4) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.06 Pain Relevance 0.36
To localize the PER2::LUC signal within the retina, we imaged vertical retinal slices for both bright-field and luminescence with a cooled charge-coupled device (CCD) camera.
Localization (localize) of LUC in retina
5) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.15 Pain Relevance 0.07
Imaging of PER2::LUC luminescence signals from retinal vertical slice cultures of both B6C3 and C57BL/6J mice showed that PER2::LUC rhythms were predominantly localized to the inner nuclear layer of the retina, which contains the nuclei of retinal horizontal, bipolar, and amacrine cells.
Localization (localized) of LUC in amacrine cells associated with imagery
6) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.05
M) necessary to modulate retinal PER2::LUC rhythms in these experiments are likely due to uptake by high-affinity GABA transporters present on a range of retinal neurons, as well as on retinal Müller cells [79].
Localization (modulate) of LUC in neurons associated with gaba
7) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.07 Pain Relevance 0.41
M; n = 4; Figure 4J) did not exhibit marked effects on the phase, amplitude, or period of retinal PER2::LUC rhythms, although the baseline of PER2::LUC rhythms was modestly reduced.


Localization (baseline) of LUC
8) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.58
M) necessary to modulate retinal PER2::LUC rhythms in these experiments are likely due to uptake by high-affinity GABA transporters present on a range of retinal neurons, as well as on retinal Müller cells [79].
Localization (retinal) of LUC in neurons associated with gaba
9) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.07 Pain Relevance 0.41
The finding that GABA acts on the retinal PER2::LUC rhythms through ionotropic, Cl?
Localization (retinal) of LUC associated with gaba
10) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.58
To determine whether dopamine acting through D1 receptors mediates light resetting of retinal PER2::LUC rhythms, we applied the D1 receptor antagonist SCH-23390 (50 ?
Localization (resetting) of LUC associated with dopamine and antagonist
11) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.32
Food deprivation alters the phase of peak PER2::LUC in the ME/PT
Localization (phase) of LUC
12) Confidence 0.08 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.48 Pain Relevance 0

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