INT207851

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.42
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
osteoblasts 1
carotid artery 1
inferior 1
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Patient controlled alalgesia 42 100.00 Very High Very High Very High
Perioperative pain 34 99.48 Very High Very High Very High
Inflammation 49 96.00 Very High Very High Very High
cytokine 24 94.96 High High
metalloproteinase 37 91.16 High High
Pain management 16 89.96 High High
Pain 66 89.44 High High
Morphine 30 89.24 High High
addiction 1 86.80 High High
depression 6 85.12 High High
Disease Link Frequency Relevance Heat
Anaphylaxis 33 100.00 Very High Very High Very High
Post Operative Pain 36 99.48 Very High Very High Very High
Calcification 138 99.20 Very High Very High Very High
INFLAMMATION 49 96.00 Very High Very High Very High
Disease 38 95.68 Very High Very High Very High
Osteoporosis 12 95.00 High High
Metastasis 3 91.12 High High
Pain 98 89.52 High High
Adhesions 6 87.72 High High
Hypersensitivity 65 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It will be of interest to see if the implicated NPP1 sequence variants affect NPP1 expression and function.
Spec (implicated) Regulation (affect) of NPP1
1) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.96 Pain Relevance 0.26
This review focuses on the functions of NPP1 in the regulation of physiologic and pathologic calcification, principally via PPi generation from nucleoside triphosphates in tissues (and cells) including cartilage (and chondrocytes), bone (and osteoblasts), and large arteries (and smooth muscle cells (SMCs)).


Regulation (regulation) of NPP1 in osteoblasts associated with calcification
2) Confidence 0.27 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.49 Pain Relevance 0
As such, PPi generation can both suppress and promote HA crystal deposition, depending on relative tissue levels of NPP1 and alkaline phosphatase (Figure 2) [16–21, 27, 28].
Regulation (depending) of NPP1
3) Confidence 0.12 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.53 Pain Relevance 0.06
The lowest tested dose of 1.0 mg/kg showed no effect on the PCA reaction yet.
Neg (no) Regulation (effect) of PCA associated with anaphylaxis
4) Confidence 0.08 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.76 Pain Relevance 0.15
The postoperative pain regimen includes patient-controlled analgesia (PCA) for the first 3 days, with conversion to oral narcotics on the morning of the third postoperative day (ie, POD 3).
Regulation (controlled) of PCA associated with patient controlled alalgesia and perioperative pain
5) Confidence 0.05 Published 2010 Journal Eplasty Section Body Doc Link PMC2941188 Disease Relevance 0.77 Pain Relevance 1.06
In our institution, the postoperative pain regimen for patients undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction is standardized using patient-controlled analgesia (PCA) followed by conversion to oral narcotics.
Regulation (controlled) of PCA in inferior associated with patient controlled alalgesia and perioperative pain
6) Confidence 0.05 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2941188 Disease Relevance 0.74 Pain Relevance 1.25
In order to increase the lucidity of the figure the PCA has been modified by presenting the OXANO values as mean values before, during and after clamping the carotid artery.
Regulation (modified) of PCA in carotid artery
7) Confidence 0.04 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.18 Pain Relevance 0.18

General Comments

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