INT208244

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.92
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
nerve 2
epithelial cells 2
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 49 100.00 Very High Very High Very High
fluoxetine 47 100.00 Very High Very High Very High
chemokine 205 99.04 Very High Very High Very High
Inflammation 49 93.08 High High
antidepressant 45 86.96 High High
spinal stenosis 6 68.64 Quite High
Inflammatory mediators 2 54.16 Quite High
Sciatic nerve 30 51.04 Quite High
Demyelination 94 50.00 Quite Low
nociceptor 12 35.72 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 56 99.92 Very High Very High Very High
INFLAMMATION 58 93.08 High High
Injury 28 90.96 High High
Spinal Stenosis 6 68.64 Quite High
Asthma 16 55.12 Quite High
Demyelinating Disease 96 50.00 Quite Low
Sepsis 19 31.08 Quite Low
Death 2 20.48 Low Low
Diarrhoea 1 10.68 Low Low
Pain 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANTES expression was absent in the L4/L5 DRG in vehicle treated rats (Fig 7A).
Regulation (absent) of Neg (absent) Gene_expression (expression) of RANTES
1) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 0.06
We used in situ hybridization to study the levels of RANTES expression, one known ligand for CCR5, in the DRG ipsilateral and contralateral to the nerve injury.
Regulation (levels) of Gene_expression (expression) of RANTES in nerve associated with nervous system injury
2) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.74 Pain Relevance 0.03
Thus, we examined the effect of desipramine and fluoxetine on RANTES production in A549 lung epithelial cells.
Spec (examined) Regulation (effect) of Gene_expression (production) of RANTES in epithelial cells associated with desipramine and fluoxetine
3) Confidence 0.06 Published 2007 Journal Respir Res Section Body Doc Link PMC1876225 Disease Relevance 0.38 Pain Relevance 0.92

General Comments

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