INT20856

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
Anatomy Link Frequency
pacemaker neurons 1
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.08 Very High Very High Very High
Catecholamine 2 96.36 Very High Very High Very High
adenocard 4 80.00 Quite High
Clonidine 1 68.92 Quite High
antagonist 2 64.92 Quite High
beta blocker 2 54.80 Quite High
tetrodotoxin 1 40.72 Quite Low
Enkephalin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumoconiosis 6 8.84 Low Low
Stress 9 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Excitation of rostral medullary pacemaker neurons with putative sympathoexcitatory function by cyclic AMP and beta-adrenoceptor agonists 'in vitro'.
AMP Binding (Excitation) of in pacemaker neurons associated with agonist
1) Confidence 0.36 Published 1990 Journal Brain Res. Section Title Doc Link 2158855 Disease Relevance 0 Pain Relevance 0.30
By adding catalase or ethanol, these species limit the availability of H2O2 and •OH to react with adenine.
adenine Binding (react) of
2) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
However, when both Fenton reagents are combined, they react to form •OH and the absorbance associated with adenine at 260 nm decreases.
adenine Binding (associated) of
3) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
The findings presented here show that adenine will react with both Fenton and pyrite-generated •OH by addition reactions to form 8-oxoadenine and, to a lesser extent, 2-hydroxyadenine.
adenine Binding (react) of
4) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.04

General Comments

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