INT20856

Context Info Confidence 0.36 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0 Pain Relevance 0.34

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT) nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)

Anatomy Link Frequency pacemaker neurons 1 APRT (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 99.08 Catecholamine 2 96.36 adenocard 4 80.00 Clonidine 1 68.92 antagonist 2 64.92 beta blocker 2 54.80 tetrodotoxin 1 40.72 Enkephalin 3 5.00

Disease Link Frequency Relevance Heat Pneumoconiosis 6 8.84 Stress 9 5.00 Aging 3 5.00 Disease 3 5.00 Toxicity 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Excitation of rostral medullary pacemaker neurons with putative sympathoexcitatory function by cyclic AMP and beta-adrenoceptor agonists 'in vitro'.

AMP Binding (Excitation) of in pacemaker neurons associated with agonist

1) Confidence 0.36 Published 1990 Journal Brain Res. Section Title Doc Link 2158855 Disease Relevance 0 Pain Relevance 0.30

By adding catalase or ethanol, these species limit the availability of H2O2 and •OH to react with adenine.

adenine Binding (react) of

2) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0

However, when both Fenton reagents are combined, they react to form •OH and the absorbance associated with adenine at 260 nm decreases.

adenine Binding (associated) of

3) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0

The findings presented here show that adenine will react with both Fenton and pyrite-generated •OH by addition reactions to form 8-oxoadenine and, to a lesser extent, 2-hydroxyadenine.

adenine Binding (react) of

4) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.04

General Comments

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