INT208566

Context Info Confidence 0.47 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.37 Pain Relevance 0.46

cytosol (RPL13A) structural constituent of ribosome (RPL13A) ribosome (RPL13A) translation (RPL13A)

Anatomy Link Frequency connective tissues 1 RPL13A (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 50 94.16 Pain 2 35.44

Disease Link Frequency Relevance Heat Osteoarthritis 56 94.16 Peripheral Arterial Disease 10 73.60 Disease 30 70.04 Rupture 2 62.08 Cleidocranial Dysplasia 2 52.60 Pain 2 35.44 Arthropathy 6 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When both sample groups were analysed together, the expression stability was reduced (M value = 0.57, Table 3), with SDHA and RPL13A identified as the most consistently expressed reference genes.

Gene_expression (expressed) of RPL13A

1) Confidence 0.47 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.70 Pain Relevance 0.25

The geNorm algorithm is employed to investigate the expression stability of 9 commonly used reference genes (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], beta-2-microglobulin [B2M] hydroxymethylbilane synthase [HMBS], hypoxanthine guanine phosphoribosyl transferase [HPRT], ribosomal protein L13a [RPL13A], succinate dehydrogenase flavoprotein subunit A [SDHA], TATA box binding protein [TBP] and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [YWHAZ]) [11] in normal and diseased canine connective tissues.

Gene_expression (expression) of RPL13A in connective tissues

2) Confidence 0.42 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.67 Pain Relevance 0.22

General Comments

This test has worked.