INT208611

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.59
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nmbr) cytoplasm (Nmbr) signal transducer activity (Nmbr)
Anatomy Link Frequency
cochlear hair cells 2
neurons 1
Nmbr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
conotoxin 12 99.78 Very High Very High Very High
Pain 52 99.16 Very High Very High Very High
Mechanotransduction 28 98.44 Very High Very High Very High
withdrawal 24 96.40 Very High Very High Very High
Calcium channel 8 82.64 Quite High
nociceptor 64 81.52 Quite High
Mechanosensation 24 78.24 Quite High
antagonist 20 77.84 Quite High
ASIC 12 76.88 Quite High
Pain threshold 12 75.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 32 96.96 Very High Very High Very High
Pain 52 90.56 High High
Ganglion Cysts 4 65.24 Quite High
Rheumatoid Arthritis 80 21.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novel conotoxin analogue, NMB-1, is a potent and selective inhibitor of slowly but not rapidly adapting mechanically activated currents in cultured DRG neurons.
Negative_regulation (inhibitor) of NMB-1 in neurons associated with conotoxin
1) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.23 Pain Relevance 0.43
Unexpectedly, NMB-1 was found to also be an inhibitor of rapid FM1-43 loading (a measure of mechanotransduction) in cochlear hair cells.
Negative_regulation (inhibitor) of NMB-1 in cochlear hair cells associated with mechanotransduction
2) Confidence 0.23 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1885214 Disease Relevance 0.20 Pain Relevance 0.38
NMB-1 blocks mechanotransducing ion channels in cochlear hair cells
Negative_regulation (blocks) of NMB-1 in cochlear hair cells
3) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.10 Pain Relevance 0.03
NMB-1 is a novel peptide inhibitor of a subclass of mechanosensory ion channels
Negative_regulation (inhibitor) of NMB-1
4) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1885214 Disease Relevance 0.06 Pain Relevance 0.60

General Comments

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