INT208915

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.02
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
J82 1
skeletal muscle 1
bladder 1
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 66 99.52 Very High Very High Very High
Inflammation 84 58.68 Quite High
Serotonin 3 23.44 Low Low
antagonist 15 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
interstitial cystitis 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 98.60 Very High Very High Very High
Toxicity 4 97.36 Very High Very High Very High
Muscular Dystrophy 2 92.00 High High
Disease 32 90.08 High High
Cancer 12 66.60 Quite High
Hypopituitarism 22 60.64 Quite High
INFLAMMATION 99 58.68 Quite High
Myotonic Dystrophy 16 50.00 Quite Low
Bladder Disease 9 39.12 Quite Low
Natriuresis 6 35.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results show that instillation of SP into the mouse bladder increased the amount of shifted Nkx-2.5 and NF-kappaB probes that peaked at 24 hours post stimulation (Figure 9 A-D).
Positive_regulation (increased) of Nkx-2.5 in bladder associated with substance p
1) Confidence 0.29 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
To determine whether activation of NK1R increases the transcriptional activities of NF-kappaB and Nkx-2.5, an EMSA was performed.
Spec (whether) Positive_regulation (increases) of Nkx-2.5
2) Confidence 0.21 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.10
We, therefore, generated preliminary results using an urothelial cell line (J82) which indicated a constitutive activation of both NF-kappaB and NKx-2.5 in the absence of overt stimulation (data not shown).
Positive_regulation (activation) of NKx-2.5 in J82
3) Confidence 0.20 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.18 Pain Relevance 0.06
Moreover, overexpression of DMPK 3' UTR mRNA in mouse skeletal muscle also induced transcriptional activation of Nkx2-5 and its targets.
Positive_regulation (activation) of Nkx2-5 in skeletal muscle
4) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0
Levels of NKX2-5 increased in cardiac tissue in a reversible transgenic mouse model for RNA toxicity [43].
Positive_regulation (increased) of NKX2-5 associated with targeted disruption and toxicity
5) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0

General Comments

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